Association between BMI and cause-specific long-term mortality in acute myocardial infarction patients
Aims: To investigate the association between body mass index (BMI) at acute myocardial infarction (AMI) and all-cause as well as cause-specific long-term mortality. Methods: The analysis was based on 10,651 hospitalized AMI patients (age 25–84 years) recorded by the population-based Myocardial Infar...
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Elsevier
2025-03-01
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| Series: | American Journal of Preventive Cardiology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S266666772400268X |
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| author | Timo Schmitz Dennis Freuer Philip Raake Jakob Linseisen Christa Meisinger |
| author_facet | Timo Schmitz Dennis Freuer Philip Raake Jakob Linseisen Christa Meisinger |
| author_sort | Timo Schmitz |
| collection | DOAJ |
| description | Aims: To investigate the association between body mass index (BMI) at acute myocardial infarction (AMI) and all-cause as well as cause-specific long-term mortality. Methods: The analysis was based on 10,651 hospitalized AMI patients (age 25–84 years) recorded by the population-based Myocardial Infarction Registry Augsburg between 2000 and 2017. The median follow-up time was 6.7 years [IQR: 3.5–10.0)]. Cause-specific mortality was obtained by evaluating the death certificates. In multivariable-adjusted COX regression models using cubic splines for the variable BMI, the association between BMI and cause-specific mortality (all-cause, cardiovascular, ischemic heart diseases, cancer) was investigated. Additionally, a subgroup analysis in three age groups was performed for all-cause mortality. Results: Overall, there was a statistically significant U-shaped association between BMI at AMI and long-term mortality with the lowest hazard ratios (HR) found for BMI values between 25 and 30 kg/m². For cancer mortality, higher BMI values > 30 kg/m² were not associated with higher mortality. In patients aged <60 years, there was a significant association between BMI values >35 kg/m² and increased all-cause mortality; this association was missing in 60 to 84 years old patients. For all groups and for each specific cause of mortality, lower BMI (<25kg/m²) values were significantly associated with higher mortality. Conclusions: Overall, a lower BMI – and also a high BMI in patients younger than 60 years - seem to be a risk factors for increased all-cause mortality after AMI. A BMI in a mid-range between 25 and 30 kg/m² is favorable in terms of long-term survival after AMI. |
| format | Article |
| id | doaj-art-c16fc0c3dd584c069d50b20ee8048eeb |
| institution | Kabale University |
| issn | 2666-6677 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | American Journal of Preventive Cardiology |
| spelling | doaj-art-c16fc0c3dd584c069d50b20ee8048eeb2024-12-08T06:13:04ZengElsevierAmerican Journal of Preventive Cardiology2666-66772025-03-0121100899Association between BMI and cause-specific long-term mortality in acute myocardial infarction patientsTimo Schmitz0Dennis Freuer1Philip Raake2Jakob Linseisen3Christa Meisinger4Epidemiology, Medical Faculty, University of Augsburg, Augsburg, Germany; Corresponding author.Epidemiology, Medical Faculty, University of Augsburg, Augsburg, GermanyUniversity Hospital Augsburg, Department of Cardiology, Respiratory Medicine and Intensive Care, Augsburg, GermanyEpidemiology, Medical Faculty, University of Augsburg, Augsburg, GermanyEpidemiology, Medical Faculty, University of Augsburg, Augsburg, GermanyAims: To investigate the association between body mass index (BMI) at acute myocardial infarction (AMI) and all-cause as well as cause-specific long-term mortality. Methods: The analysis was based on 10,651 hospitalized AMI patients (age 25–84 years) recorded by the population-based Myocardial Infarction Registry Augsburg between 2000 and 2017. The median follow-up time was 6.7 years [IQR: 3.5–10.0)]. Cause-specific mortality was obtained by evaluating the death certificates. In multivariable-adjusted COX regression models using cubic splines for the variable BMI, the association between BMI and cause-specific mortality (all-cause, cardiovascular, ischemic heart diseases, cancer) was investigated. Additionally, a subgroup analysis in three age groups was performed for all-cause mortality. Results: Overall, there was a statistically significant U-shaped association between BMI at AMI and long-term mortality with the lowest hazard ratios (HR) found for BMI values between 25 and 30 kg/m². For cancer mortality, higher BMI values > 30 kg/m² were not associated with higher mortality. In patients aged <60 years, there was a significant association between BMI values >35 kg/m² and increased all-cause mortality; this association was missing in 60 to 84 years old patients. For all groups and for each specific cause of mortality, lower BMI (<25kg/m²) values were significantly associated with higher mortality. Conclusions: Overall, a lower BMI – and also a high BMI in patients younger than 60 years - seem to be a risk factors for increased all-cause mortality after AMI. A BMI in a mid-range between 25 and 30 kg/m² is favorable in terms of long-term survival after AMI.http://www.sciencedirect.com/science/article/pii/S266666772400268XBMIAcute myocardial infarctionLong-term mortalityCause-specific mortality |
| spellingShingle | Timo Schmitz Dennis Freuer Philip Raake Jakob Linseisen Christa Meisinger Association between BMI and cause-specific long-term mortality in acute myocardial infarction patients American Journal of Preventive Cardiology BMI Acute myocardial infarction Long-term mortality Cause-specific mortality |
| title | Association between BMI and cause-specific long-term mortality in acute myocardial infarction patients |
| title_full | Association between BMI and cause-specific long-term mortality in acute myocardial infarction patients |
| title_fullStr | Association between BMI and cause-specific long-term mortality in acute myocardial infarction patients |
| title_full_unstemmed | Association between BMI and cause-specific long-term mortality in acute myocardial infarction patients |
| title_short | Association between BMI and cause-specific long-term mortality in acute myocardial infarction patients |
| title_sort | association between bmi and cause specific long term mortality in acute myocardial infarction patients |
| topic | BMI Acute myocardial infarction Long-term mortality Cause-specific mortality |
| url | http://www.sciencedirect.com/science/article/pii/S266666772400268X |
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