Orthogonal validation of PROTAC mediated degradation of the integral membrane proteins EGFR and c-MET

Orthogonal validation of PROTAC mediated degradation of the integral membrane proteins EGFR and c-MET

Abstract Dysregulation of integral membrane proteins (IMPs) has been linked to a myriad of diseases, making these proteins an attractive target in drug research. Whilst PROTAC technology has had a significant impact in scientific research, its application to IMPs is still limited. Limitations of the...

Full description

Saved in:
Bibliographic Details
Main Authors: Camilla Ruffilli, Sascha Röth, Noam Zelcer, Kevin Moreau
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
PROTAC
Targeted protein degradation
Integral membrane protein
EGFR
c-MET
Online Access:https://doi.org/10.1038/s41598-024-84217-2
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items