Increased expression levels of PIEZO1 in visceral adipose tissue in obesity and type 2 diabetes are triggered by mechanical forces and are associated with inflammation

Increased expression levels of PIEZO1 in visceral adipose tissue in obesity and type 2 diabetes are triggered by mechanical forces and are associated with inflammation

Abstract Background PIEZO1 has emerged as a mechanoreceptor linked with adipogenesis, adipose tissue (AT) inflammation and insulin resistance. We aimed to determine the impact of obesity and obesity-associated type 2 diabetes (T2D) as well as mechanical compression forces on the expression of PIEZO1...

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Main Authors: Victoria Catalán, Javier Gómez-Ambrosi, Beatriz Ramírez, Xabier Unamuno, Sara Becerril, Amaia Rodríguez, Jorge Baixauli, Gabriel Reina, Ana Sancho, Camilo Silva, Javier A. Cienfuegos, Gema Frühbeck
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Molecular Medicine
Subjects:
PIEZO1
VAT
Mechanotransduction
Inflammation
Obesity
Type 2 diabetes
Online Access:https://doi.org/10.1186/s10020-024-01008-1
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