Hyperbaric Oxygen Therapy Increases Brain-Derived Neurotrophic Factor as well as Decreases Systemic Immune-Inflammatory Index and Systemic Inflammatory Response Index in Autism Spectrum Disorder
BACKGROUND: Neuroinflammation and immune dysregulation are frequently viewed as contributing factors of autism spectrum disorder (ASD). Brain-derived neurotrophic factor (BDNF) is involved in the maintenance of neuron viability, as well as in neuron differentiation. Meanwhile, Systemic Immune-Inflam...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Secretariat of The Indonesian Biomedical Journal
2024-12-01
|
| Series: | Indonesian Biomedical Journal |
| Online Access: | https://inabj.org/index.php/ibj/article/view/3358 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841558866560548864 |
|---|---|
| author | Verna Biutifasari Ni Komang Sri Dewi Untari Pramita Anindya Nugraheni Ronald Pratama Adiwinoto Djatiwidodo Edi Pratiknya Vendra Setiawan Hartono Kahar Betty Agustina Tambunan |
| author_facet | Verna Biutifasari Ni Komang Sri Dewi Untari Pramita Anindya Nugraheni Ronald Pratama Adiwinoto Djatiwidodo Edi Pratiknya Vendra Setiawan Hartono Kahar Betty Agustina Tambunan |
| author_sort | Verna Biutifasari |
| collection | DOAJ |
| description | BACKGROUND: Neuroinflammation and immune dysregulation are frequently viewed as contributing factors of autism spectrum disorder (ASD). Brain-derived neurotrophic factor (BDNF) is involved in the maintenance of neuron viability, as well as in neuron differentiation. Meanwhile, Systemic Immune-Inflammatory Index (SII) and Systemic Inflammatory Response Index (SIRI) are basic hematological indices used to assess inflammation and immune status. Hyperbaric oxygen (HBO) is known to enhance cerebral blood flow and reduce inflammation, however, not many studies have observed the its effect on BDNF level, SII, and SIRI in ASD subjects; therefore, this study was performed.
METHODS: Fifteen ASD subjects were involved in this study and received HBO therapy 10 times within a 2-week period. The HBO therapy was performed by letting the subjects got into an isolated chamber filled with 100% oxygen and 1.3 ATA pressure for 60 minutes. Pre- and post-therapy blood samples were taken from subjects. BDNF level was measured with Enzyme Linked Immunosorbent Assay (ELISA), while neutrophils, monocytes, lymphocytes and platelets were measured by hematology analyzer for the calculation of SII and SIRI.
RESULTS: Post-therapy BDNF level was higher than pre-therapy (1.84 ng/mL vs. 1.46 ng/mL; p=0.039). The increased in BDNF suggested reduced neuroinflammation and enhanced connections between neurons. Both post-therapy SII (672.4 vs. 359.4; p=0.005) and SIRI (1.3 vs. 0.7; p=0.009) were significantly lower than pre-therapy indexes. Decreased in SII and SIRI signified a reduction in neuroinflammation.
CONCLUSION: HBO therapy increases BDNF level, also decreases SII and SIRI in ASD subjects. These results suggest that HBO has an effect on neuroinflammation, specifically in ameliorating inflammation.
KEYWORDS: autism spectrum disorder, BDNF, SII, SIRI, hyperbaric oxygen therapy |
| format | Article |
| id | doaj-art-c111f14f571a4634b34dc23ca80a468c |
| institution | Kabale University |
| issn | 2085-3297 2355-9179 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Secretariat of The Indonesian Biomedical Journal |
| record_format | Article |
| series | Indonesian Biomedical Journal |
| spelling | doaj-art-c111f14f571a4634b34dc23ca80a468c2025-01-06T02:04:18ZengSecretariat of The Indonesian Biomedical JournalIndonesian Biomedical Journal2085-32972355-91792024-12-01166534910.18585/inabj.v16i6.3358607Hyperbaric Oxygen Therapy Increases Brain-Derived Neurotrophic Factor as well as Decreases Systemic Immune-Inflammatory Index and Systemic Inflammatory Response Index in Autism Spectrum DisorderVerna Biutifasari0Ni Komang Sri Dewi Untari1Pramita Anindya Nugraheni2Ronald Pratama Adiwinoto3Djatiwidodo Edi Pratiknya4Vendra Setiawan5Hartono Kahar6Betty Agustina Tambunan7Clinical Pathology Sub-Specialist Doctor Education Program, Department of Clinical Pathology, Faculty of Medicine, Universitas Airlangga/Dr. Soetomo General Academic Hospital, Jl. Prof. Dr. Moestopo No.47, Surabaya 60132Department of Hyperbaric, Naval Health Institute (LAKESLA) Drs. Med. R. Rijadi Sastropanoelar, Phys, Jl. Sarwajala No.2, Surabaya 60155Departement of Pediatric, Faculty of Medicine, Universitas Hang Tuah, Komplek Barat RSAL Dr. Ramelan, Jl. Gadung No. 1, Surabaya 60244Department of Community Medicine. Faculty of Medicine, Universitas Hang Tuah, Komplek Barat RSAL Dr. Ramelan, Jl. Gadung No. 1, Surabaya 60244Department of Marine Health, Faculty of Medicine, Universitas Hang Tuah, Komplek Barat RSAL Dr. Ramelan, Jl. Gadung No. 1, Surabaya 60244Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Surabaya, Jl. Raya Kalirungkut, Surabaya 60293Department of Clinical Pathology, Faculty of Medicine, Universitas Airlangga/Dr. Soetomo General Academic Hospital, Jl. Prof. Dr. Moestopo No.47, Surabaya 60132Department of Clinical Pathology, Faculty of Medicine, Universitas Airlangga/Dr. Soetomo General Academic Hospital, Jl. Prof. Dr. Moestopo No.47, Surabaya 60132BACKGROUND: Neuroinflammation and immune dysregulation are frequently viewed as contributing factors of autism spectrum disorder (ASD). Brain-derived neurotrophic factor (BDNF) is involved in the maintenance of neuron viability, as well as in neuron differentiation. Meanwhile, Systemic Immune-Inflammatory Index (SII) and Systemic Inflammatory Response Index (SIRI) are basic hematological indices used to assess inflammation and immune status. Hyperbaric oxygen (HBO) is known to enhance cerebral blood flow and reduce inflammation, however, not many studies have observed the its effect on BDNF level, SII, and SIRI in ASD subjects; therefore, this study was performed. METHODS: Fifteen ASD subjects were involved in this study and received HBO therapy 10 times within a 2-week period. The HBO therapy was performed by letting the subjects got into an isolated chamber filled with 100% oxygen and 1.3 ATA pressure for 60 minutes. Pre- and post-therapy blood samples were taken from subjects. BDNF level was measured with Enzyme Linked Immunosorbent Assay (ELISA), while neutrophils, monocytes, lymphocytes and platelets were measured by hematology analyzer for the calculation of SII and SIRI. RESULTS: Post-therapy BDNF level was higher than pre-therapy (1.84 ng/mL vs. 1.46 ng/mL; p=0.039). The increased in BDNF suggested reduced neuroinflammation and enhanced connections between neurons. Both post-therapy SII (672.4 vs. 359.4; p=0.005) and SIRI (1.3 vs. 0.7; p=0.009) were significantly lower than pre-therapy indexes. Decreased in SII and SIRI signified a reduction in neuroinflammation. CONCLUSION: HBO therapy increases BDNF level, also decreases SII and SIRI in ASD subjects. These results suggest that HBO has an effect on neuroinflammation, specifically in ameliorating inflammation. KEYWORDS: autism spectrum disorder, BDNF, SII, SIRI, hyperbaric oxygen therapyhttps://inabj.org/index.php/ibj/article/view/3358 |
| spellingShingle | Verna Biutifasari Ni Komang Sri Dewi Untari Pramita Anindya Nugraheni Ronald Pratama Adiwinoto Djatiwidodo Edi Pratiknya Vendra Setiawan Hartono Kahar Betty Agustina Tambunan Hyperbaric Oxygen Therapy Increases Brain-Derived Neurotrophic Factor as well as Decreases Systemic Immune-Inflammatory Index and Systemic Inflammatory Response Index in Autism Spectrum Disorder Indonesian Biomedical Journal |
| title | Hyperbaric Oxygen Therapy Increases Brain-Derived Neurotrophic Factor as well as Decreases Systemic Immune-Inflammatory Index and Systemic Inflammatory Response Index in Autism Spectrum Disorder |
| title_full | Hyperbaric Oxygen Therapy Increases Brain-Derived Neurotrophic Factor as well as Decreases Systemic Immune-Inflammatory Index and Systemic Inflammatory Response Index in Autism Spectrum Disorder |
| title_fullStr | Hyperbaric Oxygen Therapy Increases Brain-Derived Neurotrophic Factor as well as Decreases Systemic Immune-Inflammatory Index and Systemic Inflammatory Response Index in Autism Spectrum Disorder |
| title_full_unstemmed | Hyperbaric Oxygen Therapy Increases Brain-Derived Neurotrophic Factor as well as Decreases Systemic Immune-Inflammatory Index and Systemic Inflammatory Response Index in Autism Spectrum Disorder |
| title_short | Hyperbaric Oxygen Therapy Increases Brain-Derived Neurotrophic Factor as well as Decreases Systemic Immune-Inflammatory Index and Systemic Inflammatory Response Index in Autism Spectrum Disorder |
| title_sort | hyperbaric oxygen therapy increases brain derived neurotrophic factor as well as decreases systemic immune inflammatory index and systemic inflammatory response index in autism spectrum disorder |
| url | https://inabj.org/index.php/ibj/article/view/3358 |
| work_keys_str_mv | AT vernabiutifasari hyperbaricoxygentherapyincreasesbrainderivedneurotrophicfactoraswellasdecreasessystemicimmuneinflammatoryindexandsystemicinflammatoryresponseindexinautismspectrumdisorder AT nikomangsridewiuntari hyperbaricoxygentherapyincreasesbrainderivedneurotrophicfactoraswellasdecreasessystemicimmuneinflammatoryindexandsystemicinflammatoryresponseindexinautismspectrumdisorder AT pramitaanindyanugraheni hyperbaricoxygentherapyincreasesbrainderivedneurotrophicfactoraswellasdecreasessystemicimmuneinflammatoryindexandsystemicinflammatoryresponseindexinautismspectrumdisorder AT ronaldpratamaadiwinoto hyperbaricoxygentherapyincreasesbrainderivedneurotrophicfactoraswellasdecreasessystemicimmuneinflammatoryindexandsystemicinflammatoryresponseindexinautismspectrumdisorder AT djatiwidodoedipratiknya hyperbaricoxygentherapyincreasesbrainderivedneurotrophicfactoraswellasdecreasessystemicimmuneinflammatoryindexandsystemicinflammatoryresponseindexinautismspectrumdisorder AT vendrasetiawan hyperbaricoxygentherapyincreasesbrainderivedneurotrophicfactoraswellasdecreasessystemicimmuneinflammatoryindexandsystemicinflammatoryresponseindexinautismspectrumdisorder AT hartonokahar hyperbaricoxygentherapyincreasesbrainderivedneurotrophicfactoraswellasdecreasessystemicimmuneinflammatoryindexandsystemicinflammatoryresponseindexinautismspectrumdisorder AT bettyagustinatambunan hyperbaricoxygentherapyincreasesbrainderivedneurotrophicfactoraswellasdecreasessystemicimmuneinflammatoryindexandsystemicinflammatoryresponseindexinautismspectrumdisorder |