State of catecxolaminergine systems of the brain in forming of sydnocarb psychosis
Violations of mnestic reactions are one of substantial signs of disorders of nervous activity. On the basis of it, as a criterion of forming of experimental psychosis, in our supervisions, the state of processes of conditionally-reflex memory was studied in rats. To cover up mechanisms of derangemen...
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Dnipro State Medical University
2014-03-01
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| Series: | Medičnì Perspektivi |
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| Online Access: | http://medpers.dsma.dp.ua/issues/2014/N1/69-76.pdf |
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| author | Al Nasir Eiad Kharaponova H.B. Alnukari Abdul Karim Demchenco H.N. Drozdov A.L. |
| author_facet | Al Nasir Eiad Kharaponova H.B. Alnukari Abdul Karim Demchenco H.N. Drozdov A.L. |
| author_sort | Al Nasir Eiad |
| collection | DOAJ |
| description | Violations of mnestic reactions are one of substantial signs of disorders of nervous activity. On the basis of it, as a criterion of forming of experimental psychosis, in our supervisions, the state of processes of conditionally-reflex memory was studied in rats. To cover up mechanisms of derangements of conditionally reflex activity in the process of forming of psychotic symptomatic complex, maintenance of adrenalin, noradrenalinum and neurospecific albumen S - 100 in the brain structures, that take a direct part in the processes of memory was studied. Derangements of cognitive function, that are the result of neurotoxic action of sydnocarb, are related to reduction of maintenance of noradrenalinum in the frontal cortex, as well as adrenalin in the pons varolii. That is, sydnocarb psychosis is accompanied by reduction of activating role of the cortex and trunk structures, negatively affecting the state of mnestic reactions. In the hippocampus and striate body excitation causes violation of memory processes and on the contrary, concentration of noradrenalinum rose. Thus, the presented model of experimental psychosis, created by subacute introduction of sydnocarb, is an adequate and alternative methodology of psychotic disorders forming in animals resulted from direct participation of the catecholaminergetic systems of CNS. |
| format | Article |
| id | doaj-art-c110fd0560c94a3a9456f30dadd59cf2 |
| institution | Kabale University |
| issn | 2307-0404 2307-0404 |
| language | English |
| publishDate | 2014-03-01 |
| publisher | Dnipro State Medical University |
| record_format | Article |
| series | Medičnì Perspektivi |
| spelling | doaj-art-c110fd0560c94a3a9456f30dadd59cf22024-12-02T00:02:52ZengDnipro State Medical UniversityMedičnì Perspektivi2307-04042307-04042014-03-011916976State of catecxolaminergine systems of the brain in forming of sydnocarb psychosisAl Nasir Eiad0Kharaponova H.B.1Alnukari Abdul Karim2Demchenco H.N.3Drozdov A.L. 4SE "Dnipropetrovsk medical academy of Health Ministry of Ukraine" Research Institute of Biomedical Problems SE «DMA»SE "Dnipropetrovsk medical academy of Health Ministry of Ukraine" Research Institute of Biomedical Problems SE «DMA»SE "Dnipropetrovsk medical academy of Health Ministry of Ukraine" Research Institute of Biomedical Problems SE «DMA»SE "Dnipropetrovsk medical academy of Health Ministry of Ukraine" Research Institute of Biomedical Problems SE «DMA»SE "Dnipropetrovsk medical academy of Health Ministry of Ukraine" Research Institute of Biomedical Problems SE «DMA»Violations of mnestic reactions are one of substantial signs of disorders of nervous activity. On the basis of it, as a criterion of forming of experimental psychosis, in our supervisions, the state of processes of conditionally-reflex memory was studied in rats. To cover up mechanisms of derangements of conditionally reflex activity in the process of forming of psychotic symptomatic complex, maintenance of adrenalin, noradrenalinum and neurospecific albumen S - 100 in the brain structures, that take a direct part in the processes of memory was studied. Derangements of cognitive function, that are the result of neurotoxic action of sydnocarb, are related to reduction of maintenance of noradrenalinum in the frontal cortex, as well as adrenalin in the pons varolii. That is, sydnocarb psychosis is accompanied by reduction of activating role of the cortex and trunk structures, negatively affecting the state of mnestic reactions. In the hippocampus and striate body excitation causes violation of memory processes and on the contrary, concentration of noradrenalinum rose. Thus, the presented model of experimental psychosis, created by subacute introduction of sydnocarb, is an adequate and alternative methodology of psychotic disorders forming in animals resulted from direct participation of the catecholaminergetic systems of CNS.http://medpers.dsma.dp.ua/issues/2014/N1/69-76.pdfbraincatecholaminsneurospecific albumen S - 100psychosis |
| spellingShingle | Al Nasir Eiad Kharaponova H.B. Alnukari Abdul Karim Demchenco H.N. Drozdov A.L. State of catecxolaminergine systems of the brain in forming of sydnocarb psychosis Medičnì Perspektivi brain catecholamins neurospecific albumen S - 100 psychosis |
| title | State of catecxolaminergine systems of the brain in forming of sydnocarb psychosis |
| title_full | State of catecxolaminergine systems of the brain in forming of sydnocarb psychosis |
| title_fullStr | State of catecxolaminergine systems of the brain in forming of sydnocarb psychosis |
| title_full_unstemmed | State of catecxolaminergine systems of the brain in forming of sydnocarb psychosis |
| title_short | State of catecxolaminergine systems of the brain in forming of sydnocarb psychosis |
| title_sort | state of catecxolaminergine systems of the brain in forming of sydnocarb psychosis |
| topic | brain catecholamins neurospecific albumen S - 100 psychosis |
| url | http://medpers.dsma.dp.ua/issues/2014/N1/69-76.pdf |
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