The Effect of Apis dorsata Honey Treatment on Calcium Levels of Mandibular Bone in Ovariohysterectomized Wistar Rats
This study aimed to evaluate the efficacy of Apis dorsata honey on calcium levels in the mandibular bone of Wistar rats after ovariohysterectomy as an animal osteoporosis model for treating cases of osteoporosis. This study used 20 female rats, which were divided into five treatment groups with four...
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Universitas Airlangga, Faculty of Veterinary Medicine
2023-12-01
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| Series: | Jurnal Medik Veteriner |
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| Online Access: | https://e-journal.unair.ac.id/JMV/article/view/46209 |
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| author | Siti Nur Rohmah Ira Sari Yudaniayanti Hardany Primarizky Poedji Hastutiek |
| author_facet | Siti Nur Rohmah Ira Sari Yudaniayanti Hardany Primarizky Poedji Hastutiek |
| author_sort | Siti Nur Rohmah |
| collection | DOAJ |
| description | This study aimed to evaluate the efficacy of Apis dorsata honey on calcium levels in the mandibular bone of Wistar rats after ovariohysterectomy as an animal osteoporosis model for treating cases of osteoporosis. This study used 20 female rats, which were divided into five treatment groups with four replications. SHAM was the negative control group; OH was the ovariohysterectomized group without treatment as a positive control; the AD1, AD2, and AD3 groups were ovariohysterectomized rats with A. dorsata honey at doses of 1 g/kg bw, 2 g/kg bw, and 4 g/kg bw for 84 days. After 84 days of treatment, the left mandibular bones of the rats were collected, weighed, and stored in 10% neutral buffered formalin. Calcium levels were calculated using proximate analysis. The results showed a decrease in bone calcium levels in the ovariohysterectomy group, the highest results were in the SHAM group, and the lowest results were in the AD3 group. It can be concluded that the administration of A. dorsata honey could not maintain the calcium level of the mandibular bone in the ovariohysterectomized Wistar rats. |
| format | Article |
| id | doaj-art-c0d389611b004b5fafb63afaf653e2ef |
| institution | Kabale University |
| issn | 2615-7497 2581-012X |
| language | English |
| publishDate | 2023-12-01 |
| publisher | Universitas Airlangga, Faculty of Veterinary Medicine |
| record_format | Article |
| series | Jurnal Medik Veteriner |
| spelling | doaj-art-c0d389611b004b5fafb63afaf653e2ef2025-01-03T01:49:51ZengUniversitas Airlangga, Faculty of Veterinary MedicineJurnal Medik Veteriner2615-74972581-012X2023-12-01631710.20473/jmv.vol6.iss3.2023.1-744295The Effect of Apis dorsata Honey Treatment on Calcium Levels of Mandibular Bone in Ovariohysterectomized Wistar RatsSiti Nur Rohmah0https://orcid.org/0009-0005-1276-6104Ira Sari Yudaniayanti1https://orcid.org/0000-0003-2994-3208Hardany Primarizky2https://orcid.org/0000-0001-9537-3931Poedji Hastutiek3https://orcid.org/0000-0002-1226-5108Bachelor Program of Veterinary Medicine, Faculty of Veterinary Medicine, Universitas Airlangga, SurabayaDivision of Veterinary Clinic, Faculty of Veterinary Medicine, Universitas Airlangga, SurabayaDivision of Veterinary Clinic, Faculty of Veterinary Medicine, Universitas Airlangga, SurabayaDivision of Veterinary Parasitology, Faculty of Veterinary Medicine, Universitas Airlangga, SurabayaThis study aimed to evaluate the efficacy of Apis dorsata honey on calcium levels in the mandibular bone of Wistar rats after ovariohysterectomy as an animal osteoporosis model for treating cases of osteoporosis. This study used 20 female rats, which were divided into five treatment groups with four replications. SHAM was the negative control group; OH was the ovariohysterectomized group without treatment as a positive control; the AD1, AD2, and AD3 groups were ovariohysterectomized rats with A. dorsata honey at doses of 1 g/kg bw, 2 g/kg bw, and 4 g/kg bw for 84 days. After 84 days of treatment, the left mandibular bones of the rats were collected, weighed, and stored in 10% neutral buffered formalin. Calcium levels were calculated using proximate analysis. The results showed a decrease in bone calcium levels in the ovariohysterectomy group, the highest results were in the SHAM group, and the lowest results were in the AD3 group. It can be concluded that the administration of A. dorsata honey could not maintain the calcium level of the mandibular bone in the ovariohysterectomized Wistar rats.https://e-journal.unair.ac.id/JMV/article/view/46209apis dorsatacalcium levelshealthosteoporosisovariohysterectomy |
| spellingShingle | Siti Nur Rohmah Ira Sari Yudaniayanti Hardany Primarizky Poedji Hastutiek The Effect of Apis dorsata Honey Treatment on Calcium Levels of Mandibular Bone in Ovariohysterectomized Wistar Rats Jurnal Medik Veteriner apis dorsata calcium levels health osteoporosis ovariohysterectomy |
| title | The Effect of Apis dorsata Honey Treatment on Calcium Levels of Mandibular Bone in Ovariohysterectomized Wistar Rats |
| title_full | The Effect of Apis dorsata Honey Treatment on Calcium Levels of Mandibular Bone in Ovariohysterectomized Wistar Rats |
| title_fullStr | The Effect of Apis dorsata Honey Treatment on Calcium Levels of Mandibular Bone in Ovariohysterectomized Wistar Rats |
| title_full_unstemmed | The Effect of Apis dorsata Honey Treatment on Calcium Levels of Mandibular Bone in Ovariohysterectomized Wistar Rats |
| title_short | The Effect of Apis dorsata Honey Treatment on Calcium Levels of Mandibular Bone in Ovariohysterectomized Wistar Rats |
| title_sort | effect of apis dorsata honey treatment on calcium levels of mandibular bone in ovariohysterectomized wistar rats |
| topic | apis dorsata calcium levels health osteoporosis ovariohysterectomy |
| url | https://e-journal.unair.ac.id/JMV/article/view/46209 |
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