Refractory Immune Thrombocytopenic Purpura and Cytomegalovirus Infection: A Call for a Change in the Current Guidelines
Immune thrombocytopenic purpura (ITP) is characterized by a decreased platelet count caused by excess destruction of platelets and inadequate platelet production. In many cases the etiology is not known, but viral illness is thought to play a role in the development of some cases of ITP. The current...
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PAGEPress Publications
2016-01-01
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| Series: | Mediterranean Journal of Hematology and Infectious Diseases |
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| Online Access: | http://www.mjhid.org/index.php/mjhid/article/view/2413 |
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| author | Alex Shimanovsky Devbala Patel Jeffrey Wasser |
| author_facet | Alex Shimanovsky Devbala Patel Jeffrey Wasser |
| author_sort | Alex Shimanovsky |
| collection | DOAJ |
| description | Immune thrombocytopenic purpura (ITP) is characterized by a decreased platelet count caused by excess destruction of platelets and inadequate platelet production. In many cases the etiology is not known, but viral illness is thought to play a role in the development of some cases of ITP. The current (2011) American Society of Hematology ITP guidelines recommend initial diagnostic studies to include testing for HIV and Hepatitis C. The guidelines suggest that initial treatment consist of observation, therapy with corticosteroids, IVIG or anti D. While most cases respond to the standard therapy such that the steroids may be tapered and the platelet counts remain at a hemostatically safe level. Some patients with ITP are dependent on long term steroid maintenance and the thrombocytopenia persists with the tapering of the steroids. Recent case reports demonstrate that ITP related to cytomegalovirus (CMV) can persist in spite of standard therapy and that antiviral therapy maybe indicated. Herein we report a case of a 26-year-old female with persistent ITP that resolved after the delivery of a CMV infected infant and placenta. Furthermore we review the current literature on CMV-associated ITP and propose that the current ITP guidelines be amended to include assessment for CMV as part of the work-up for severe and refractory ITP prior to splenectomy. |
| format | Article |
| id | doaj-art-c0c92cfd23d0440eba34b17734e81db7 |
| institution | Kabale University |
| issn | 2035-3006 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Mediterranean Journal of Hematology and Infectious Diseases |
| spelling | doaj-art-c0c92cfd23d0440eba34b17734e81db72025-01-02T00:39:26ZengPAGEPress PublicationsMediterranean Journal of Hematology and Infectious Diseases2035-30062016-01-0180e2016010e201601010.4084/mjhid.2016.0101594Refractory Immune Thrombocytopenic Purpura and Cytomegalovirus Infection: A Call for a Change in the Current GuidelinesAlex Shimanovsky0Devbala Patel1Jeffrey Wasser2University of ConnecticutManchester Memorial HospitalUniversity of ConnecticutImmune thrombocytopenic purpura (ITP) is characterized by a decreased platelet count caused by excess destruction of platelets and inadequate platelet production. In many cases the etiology is not known, but viral illness is thought to play a role in the development of some cases of ITP. The current (2011) American Society of Hematology ITP guidelines recommend initial diagnostic studies to include testing for HIV and Hepatitis C. The guidelines suggest that initial treatment consist of observation, therapy with corticosteroids, IVIG or anti D. While most cases respond to the standard therapy such that the steroids may be tapered and the platelet counts remain at a hemostatically safe level. Some patients with ITP are dependent on long term steroid maintenance and the thrombocytopenia persists with the tapering of the steroids. Recent case reports demonstrate that ITP related to cytomegalovirus (CMV) can persist in spite of standard therapy and that antiviral therapy maybe indicated. Herein we report a case of a 26-year-old female with persistent ITP that resolved after the delivery of a CMV infected infant and placenta. Furthermore we review the current literature on CMV-associated ITP and propose that the current ITP guidelines be amended to include assessment for CMV as part of the work-up for severe and refractory ITP prior to splenectomy.http://www.mjhid.org/index.php/mjhid/article/view/2413Immune Thrombocytopenic Purpura, ITP, Cytomegalovirus, CMV, Refractory ITP, CMV-associated ITP |
| spellingShingle | Alex Shimanovsky Devbala Patel Jeffrey Wasser Refractory Immune Thrombocytopenic Purpura and Cytomegalovirus Infection: A Call for a Change in the Current Guidelines Mediterranean Journal of Hematology and Infectious Diseases Immune Thrombocytopenic Purpura, ITP, Cytomegalovirus, CMV, Refractory ITP, CMV-associated ITP |
| title | Refractory Immune Thrombocytopenic Purpura and Cytomegalovirus Infection: A Call for a Change in the Current Guidelines |
| title_full | Refractory Immune Thrombocytopenic Purpura and Cytomegalovirus Infection: A Call for a Change in the Current Guidelines |
| title_fullStr | Refractory Immune Thrombocytopenic Purpura and Cytomegalovirus Infection: A Call for a Change in the Current Guidelines |
| title_full_unstemmed | Refractory Immune Thrombocytopenic Purpura and Cytomegalovirus Infection: A Call for a Change in the Current Guidelines |
| title_short | Refractory Immune Thrombocytopenic Purpura and Cytomegalovirus Infection: A Call for a Change in the Current Guidelines |
| title_sort | refractory immune thrombocytopenic purpura and cytomegalovirus infection a call for a change in the current guidelines |
| topic | Immune Thrombocytopenic Purpura, ITP, Cytomegalovirus, CMV, Refractory ITP, CMV-associated ITP |
| url | http://www.mjhid.org/index.php/mjhid/article/view/2413 |
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