Administration of monophosphoryl lipid A shortly after traumatic brain injury blocks the following spatial and avoidance memory loss and neuroinflammation

Administration of monophosphoryl lipid A shortly after traumatic brain injury blocks the following spatial and avoidance memory loss and neuroinflammation

Abstract Traumatic brain injury (TBI) frequently leads to cognitive impairments. The toll-like receptor 4 (TLR4) ligand, Monophosphoryl lipid A (MPL), has shown promise in modulating neuroinflammatory responses after TBI. We investigated the effects of MPL on spatial memory, passive avoidance memory...

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Bibliographic Details
Main Authors: Maryam Hooshmand, Mohammad Reza Sadeghi, Ahmad Asoodeh, Hamid Gholami Pourbadie, Mahbobeh Kamrani Mehni, Mohamad Sayyah
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
Shuttle box
Controlled cortical impact
Hippocampus
Water maze
Online Access:https://doi.org/10.1038/s41598-024-80331-3
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