中国大陆汉族人卡马西平过敏性药疹与HLA-B*1502的关联性分析
【目的】 探讨我国大陆地区汉族人群中HLA-B*1502与卡马西平引起的过敏性药疹的关联性65377;【方法】 收集48例卡马西平过敏性药疹患者,其中9例为重型过敏性药疹患者(包括Stevens-Johnson 综合征65380;中毒性表皮坏死松解症),39例为轻型过敏性药疹患者;以及80例服用卡马西平无过敏患者和62例正常对照者,采用PCR-SSP法进行HLA-B*1502的基因型测定,观察卡马西平引起过敏性药疹与HLA-B*1502基因型是否存在关联65377;【结果】 卡马西平重型过敏性药疹组HLA-B*1502基因型携带率为100%,显著高于卡马西平无过敏组(13.75%)及正常对照组...
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Format: | Article |
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Language: | zho |
Published: |
Editorial Office of Journal of Sun Yat-sen University
2010-01-01
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Series: | Zhongshan Daxue xuebao. Yixue kexue ban |
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Online Access: | http://xuebaoyx.sysu.edu.cn/zh/article/43577466/ |
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