Phytochemical characterization and multifaceted bioactivity assessment of essential oil from Clinopodium nepeta subsp. ascendens: potential for the food and pharmaceutical sectors
This study delves into the biological characteristics of Clinopodium nepeta subsp. ascendens (CNEO) essential oil, an indigenous subspecies of eastern Morocco. Distinguished by its purple or pale pinkish-white flowers, CNEO was subjected to thorough phytochemical analysis via gas chromatography-mass...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | CyTA - Journal of Food |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/19476337.2024.2348735 |
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| author | Mohamed Taibi Amine Elbouzidi Mounir Haddou Yousra Belbachir Abdellah Baraich Zineb Khalil Reda Bellaouchi Abdeslam Asehraou Mohamed Addi Ammar AL-Farga Saleh M. Al-Maaqar Bouchra El Guerrouj Khalid Chaabane |
| author_facet | Mohamed Taibi Amine Elbouzidi Mounir Haddou Yousra Belbachir Abdellah Baraich Zineb Khalil Reda Bellaouchi Abdeslam Asehraou Mohamed Addi Ammar AL-Farga Saleh M. Al-Maaqar Bouchra El Guerrouj Khalid Chaabane |
| author_sort | Mohamed Taibi |
| collection | DOAJ |
| description | This study delves into the biological characteristics of Clinopodium nepeta subsp. ascendens (CNEO) essential oil, an indigenous subspecies of eastern Morocco. Distinguished by its purple or pale pinkish-white flowers, CNEO was subjected to thorough phytochemical analysis via gas chromatography-mass spectrometry (GC-MS), revealing 21 terpene compounds, notably Dihydrocarvone (22.70%), Neoisomenthol (43.59%), and Pulegone (20.55%). These compounds, recognized for their biological and pharmacological attributes, were further investigated for their potential applications. Notably, CNEO exhibited dose-dependent anti-inflammatory effects by attenuating nitric oxide (NO) and prostaglandin E2 (PGE2) production. Moreover, it demonstrated promising anticancer activity against MDA-MB-468, HepG2, and HCT-15 cancer cell lines, rivaling doxorubicin’s effectiveness. These findings underscore CNEO’s nutraceutical potential, particularly in food science and industry, suggesting its use as a functional food additive with both nutritional and health benefits |
| format | Article |
| id | doaj-art-c09f0afacbd24a2eb2a1971cf35b9351 |
| institution | Kabale University |
| issn | 1947-6337 1947-6345 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | CyTA - Journal of Food |
| spelling | doaj-art-c09f0afacbd24a2eb2a1971cf35b93512024-12-18T13:34:51ZengTaylor & Francis GroupCyTA - Journal of Food1947-63371947-63452024-12-0122110.1080/19476337.2024.2348735Phytochemical characterization and multifaceted bioactivity assessment of essential oil from Clinopodium nepeta subsp. ascendens: potential for the food and pharmaceutical sectorsMohamed Taibi0Amine Elbouzidi1Mounir Haddou2Yousra Belbachir3Abdellah Baraich4Zineb Khalil5Reda Bellaouchi6Abdeslam Asehraou7Mohamed Addi8Ammar AL-Farga9Saleh M. Al-Maaqar10Bouchra El Guerrouj11Khalid Chaabane12Laboratoire d’Amélioration des Productions Agricoles, Biotechnologie et Environnement (LAPABE), Faculté des Sciences, Université Mohammed Premier, Oujda, MoroccoLaboratoire d’Amélioration des Productions Agricoles, Biotechnologie et Environnement (LAPABE), Faculté des Sciences, Université Mohammed Premier, Oujda, MoroccoLaboratoire d’Amélioration des Productions Agricoles, Biotechnologie et Environnement (LAPABE), Faculté des Sciences, Université Mohammed Premier, Oujda, MoroccoPhysical Chemistry of Natural Resources and Process Team, Laboratory of Applied Chemistry and Environment (LCAE), Department of Chemistry, Faculty of Sciences, Mohammed First University, Oujda, MoroccoLaboratory of Bioresources, Biotechnology, Ethnopharmacology and Health, Faculty of Sciences, Mohammed First University, Oujda, MoroccoInstitut Supérieur des Professions Infirmières et Techniques de Santé Casablanca Rue Mohamed El Faidouzi - Casablanca Maroc (Z.K), Casablanca, MarocoLaboratory of Bioresources, Biotechnology, Ethnopharmacology and Health, Faculty of Sciences, Mohammed First University, Oujda, MoroccoLaboratory of Bioresources, Biotechnology, Ethnopharmacology and Health, Faculty of Sciences, Mohammed First University, Oujda, MoroccoLaboratoire d’Amélioration des Productions Agricoles, Biotechnologie et Environnement (LAPABE), Faculté des Sciences, Université Mohammed Premier, Oujda, MoroccoDepartment of Biochemistry, Faculty of Science University of Jeddah, Jeddah, Saudi ArabiaDepartment of Biology, Faculty of Education, Albaydha University, Al-Baydha, YemenLaboratoire d’Amélioration des Productions Agricoles, Biotechnologie et Environnement (LAPABE), Faculté des Sciences, Université Mohammed Premier, Oujda, MoroccoLaboratoire d’Amélioration des Productions Agricoles, Biotechnologie et Environnement (LAPABE), Faculté des Sciences, Université Mohammed Premier, Oujda, MoroccoThis study delves into the biological characteristics of Clinopodium nepeta subsp. ascendens (CNEO) essential oil, an indigenous subspecies of eastern Morocco. Distinguished by its purple or pale pinkish-white flowers, CNEO was subjected to thorough phytochemical analysis via gas chromatography-mass spectrometry (GC-MS), revealing 21 terpene compounds, notably Dihydrocarvone (22.70%), Neoisomenthol (43.59%), and Pulegone (20.55%). These compounds, recognized for their biological and pharmacological attributes, were further investigated for their potential applications. Notably, CNEO exhibited dose-dependent anti-inflammatory effects by attenuating nitric oxide (NO) and prostaglandin E2 (PGE2) production. Moreover, it demonstrated promising anticancer activity against MDA-MB-468, HepG2, and HCT-15 cancer cell lines, rivaling doxorubicin’s effectiveness. These findings underscore CNEO’s nutraceutical potential, particularly in food science and industry, suggesting its use as a functional food additive with both nutritional and health benefitshttps://www.tandfonline.com/doi/10.1080/19476337.2024.2348735Clinopodium nepeta subsp. ascendensessential oilGC-MSbiological activitiescancer cell linesfood additive |
| spellingShingle | Mohamed Taibi Amine Elbouzidi Mounir Haddou Yousra Belbachir Abdellah Baraich Zineb Khalil Reda Bellaouchi Abdeslam Asehraou Mohamed Addi Ammar AL-Farga Saleh M. Al-Maaqar Bouchra El Guerrouj Khalid Chaabane Phytochemical characterization and multifaceted bioactivity assessment of essential oil from Clinopodium nepeta subsp. ascendens: potential for the food and pharmaceutical sectors CyTA - Journal of Food Clinopodium nepeta subsp. ascendens essential oil GC-MS biological activities cancer cell lines food additive |
| title | Phytochemical characterization and multifaceted bioactivity assessment of essential oil from Clinopodium nepeta subsp. ascendens: potential for the food and pharmaceutical sectors |
| title_full | Phytochemical characterization and multifaceted bioactivity assessment of essential oil from Clinopodium nepeta subsp. ascendens: potential for the food and pharmaceutical sectors |
| title_fullStr | Phytochemical characterization and multifaceted bioactivity assessment of essential oil from Clinopodium nepeta subsp. ascendens: potential for the food and pharmaceutical sectors |
| title_full_unstemmed | Phytochemical characterization and multifaceted bioactivity assessment of essential oil from Clinopodium nepeta subsp. ascendens: potential for the food and pharmaceutical sectors |
| title_short | Phytochemical characterization and multifaceted bioactivity assessment of essential oil from Clinopodium nepeta subsp. ascendens: potential for the food and pharmaceutical sectors |
| title_sort | phytochemical characterization and multifaceted bioactivity assessment of essential oil from clinopodium nepeta subsp ascendens potential for the food and pharmaceutical sectors |
| topic | Clinopodium nepeta subsp. ascendens essential oil GC-MS biological activities cancer cell lines food additive |
| url | https://www.tandfonline.com/doi/10.1080/19476337.2024.2348735 |
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