Progress in Epidemiological Research on Relationship Between Duration of Type 2 Diabetes and Risk of Malignant Tumors of Female Reproductive System
The relationship between the duration of type 2 diabetes mellitus (T2DM) and the risk of female reproductive malignancies is complex and multifaceted. Large population cohort studies revealed a negative association between the duration of T2DM and the incidence of breast cancer and endometrial cance...
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| Format: | Article |
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Magazine House of Cancer Research on Prevention and Treatment
2024-12-01
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| Series: | Zhongliu Fangzhi Yanjiu |
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| Online Access: | http://www.zlfzyj.com/cn/article/doi/10.3971/j.issn.1000-8578.2024.24.0754 |
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| author | Xiaohui ZHOU Zhuoying LI Wanwan LIU Peiwen LU Qiuming SHEN Qun XU Yongbing XIANG |
| author_facet | Xiaohui ZHOU Zhuoying LI Wanwan LIU Peiwen LU Qiuming SHEN Qun XU Yongbing XIANG |
| author_sort | Xiaohui ZHOU |
| collection | DOAJ |
| description | The relationship between the duration of type 2 diabetes mellitus (T2DM) and the risk of female reproductive malignancies is complex and multifaceted. Large population cohort studies revealed a negative association between the duration of T2DM and the incidence of breast cancer and endometrial cancer. Furthermore, the risk of breast and endometrial cancer is the highest within a short time after T2DM diagnosis and remains remarkably higher in patients with longer diabetes duration than in the nondiabetic population. This phenomenon suggests causal reverse bias and potential detection bias. Nevertheless, T2DM remains an important risk factor for breast and endometrial cancer. Research on the association between diabetes with cervical and ovarian cancer is limited, and results vary by region. Future epidemiological studies should focus on large prospective studies with long follow-up to further investigate this association. Research into the biological mechanisms linking diabetes and female reproductive cancers is also necessary to develop effective cancer prevention and early intervention strategies. |
| format | Article |
| id | doaj-art-c07e57b4c9c8416f94d55300b9e272b0 |
| institution | Kabale University |
| issn | 1000-8578 |
| language | zho |
| publishDate | 2024-12-01 |
| publisher | Magazine House of Cancer Research on Prevention and Treatment |
| record_format | Article |
| series | Zhongliu Fangzhi Yanjiu |
| spelling | doaj-art-c07e57b4c9c8416f94d55300b9e272b02024-12-20T06:47:22ZzhoMagazine House of Cancer Research on Prevention and TreatmentZhongliu Fangzhi Yanjiu1000-85782024-12-01511297798810.3971/j.issn.1000-8578.2024.24.075420240754Progress in Epidemiological Research on Relationship Between Duration of Type 2 Diabetes and Risk of Malignant Tumors of Female Reproductive SystemXiaohui ZHOU0Zhuoying LI1Wanwan LIU2Peiwen LU3Qiuming SHEN4Qun XU5Yongbing XIANG6School of Public Health, Shanghai Jiaotong University School of Medicine, Shanghai 200025, ChinaDepartment of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200032, ChinaHealth Management Center, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200127, ChinaHealth Management Center, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200127, ChinaDepartment of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200032, ChinaHealth Management Center, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200127, ChinaDepartment of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200032, ChinaThe relationship between the duration of type 2 diabetes mellitus (T2DM) and the risk of female reproductive malignancies is complex and multifaceted. Large population cohort studies revealed a negative association between the duration of T2DM and the incidence of breast cancer and endometrial cancer. Furthermore, the risk of breast and endometrial cancer is the highest within a short time after T2DM diagnosis and remains remarkably higher in patients with longer diabetes duration than in the nondiabetic population. This phenomenon suggests causal reverse bias and potential detection bias. Nevertheless, T2DM remains an important risk factor for breast and endometrial cancer. Research on the association between diabetes with cervical and ovarian cancer is limited, and results vary by region. Future epidemiological studies should focus on large prospective studies with long follow-up to further investigate this association. Research into the biological mechanisms linking diabetes and female reproductive cancers is also necessary to develop effective cancer prevention and early intervention strategies.http://www.zlfzyj.com/cn/article/doi/10.3971/j.issn.1000-8578.2024.24.0754type 2 diabetesfemale reproductive system cancerpotential detection biasdurationepidemiology |
| spellingShingle | Xiaohui ZHOU Zhuoying LI Wanwan LIU Peiwen LU Qiuming SHEN Qun XU Yongbing XIANG Progress in Epidemiological Research on Relationship Between Duration of Type 2 Diabetes and Risk of Malignant Tumors of Female Reproductive System Zhongliu Fangzhi Yanjiu type 2 diabetes female reproductive system cancer potential detection bias duration epidemiology |
| title | Progress in Epidemiological Research on Relationship Between Duration of Type 2 Diabetes and Risk of Malignant Tumors of Female Reproductive System |
| title_full | Progress in Epidemiological Research on Relationship Between Duration of Type 2 Diabetes and Risk of Malignant Tumors of Female Reproductive System |
| title_fullStr | Progress in Epidemiological Research on Relationship Between Duration of Type 2 Diabetes and Risk of Malignant Tumors of Female Reproductive System |
| title_full_unstemmed | Progress in Epidemiological Research on Relationship Between Duration of Type 2 Diabetes and Risk of Malignant Tumors of Female Reproductive System |
| title_short | Progress in Epidemiological Research on Relationship Between Duration of Type 2 Diabetes and Risk of Malignant Tumors of Female Reproductive System |
| title_sort | progress in epidemiological research on relationship between duration of type 2 diabetes and risk of malignant tumors of female reproductive system |
| topic | type 2 diabetes female reproductive system cancer potential detection bias duration epidemiology |
| url | http://www.zlfzyj.com/cn/article/doi/10.3971/j.issn.1000-8578.2024.24.0754 |
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