Human liver stem cells and derived extracellular vesicles protect from sepsis-induced acute lung injury and restore bone marrow myelopoiesis in a murine model of sepsis

Human liver stem cells and derived extracellular vesicles protect from sepsis-induced acute lung injury and restore bone marrow myelopoiesis in a murine model of sepsis

Abstract Background Sepsis is a condition with high mortality and morbidity, characterized by deregulation of the immune response against the pathogen. Current treatment strategies rely mainly on antibiotics and supportive care. However, there is growing interest in exploring cell-based therapies as...

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Bibliographic Details
Main Authors: Andrea Costamagna, Chiara Pasquino, Sara Lamorte, Victor Navarro-Tableros, Luisa Delsedime, Vito Fanelli, Giovanni Camussi, Lorenzo Del Sorbo
Format: Article
Language:English
Published: SpringerOpen 2024-12-01
Series:Intensive Care Medicine Experimental
Subjects:
Shock
Septic
Mesenchymal stem cells
Extracellular vesicles
Acute lung injury
Myelopoiesis
Online Access:https://doi.org/10.1186/s40635-024-00701-z
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