Amelioration of cognition by hesperidin-conjugated cobalt oxide nanoparticles

Abstract Diabetes mellitus is one of the metabolic syndromes that is associated with cognitive deficit, dementia, and Alzheimer’s disease (AD) like pathology due to impaired insulin-signalling in the brain, oxidative stress and mitochondrial dysfunction. Nanotechnology is one of the most promising t...

Full description

Saved in:
Bibliographic Details
Main Authors: Anindita Behera, Bibhanwita Satpathy, Rajesh Kumar Sahoo, Pratap Kumar Sahu
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Scientific Reports
Subjects:
Online Access:https://doi.org/10.1038/s41598-024-80320-6
Tags: Add Tag
No Tags, Be the first to tag this record!
_version_ 1846101187099623424
author Anindita Behera
Bibhanwita Satpathy
Rajesh Kumar Sahoo
Pratap Kumar Sahu
author_facet Anindita Behera
Bibhanwita Satpathy
Rajesh Kumar Sahoo
Pratap Kumar Sahu
author_sort Anindita Behera
collection DOAJ
description Abstract Diabetes mellitus is one of the metabolic syndromes that is associated with cognitive deficit, dementia, and Alzheimer’s disease (AD) like pathology due to impaired insulin-signalling in the brain, oxidative stress and mitochondrial dysfunction. Nanotechnology is one of the most promising techniques for targeting the brain. However, the toxicity of metal nanoparticles is one of the biggest challenges to be studied. In this study, cobalt oxide nanoparticles are conjugated to a bioflavonoid, hesperidin, a natural antioxidant. The study is designed to assess the efficacy and safety of the cobalt oxide conjugated hesperidin in the diabetes-induced cognitive deficit rat model. The neuropharmacological behaviour, in-vivo antioxidant status and level of acetylcholinesterase, nitrite, amyloid β, and pro-inflammatory cytokines were determined for cobalt oxide conjugated hesperidin and compared with bare cobalt oxide nanoparticles and hesperidin. The cobalt oxide conjugated hesperidin significantly improved learning and memory in the streptozotocin rat model. However, further studies are required to establish a cellular and molecular mechanism involved in the neuroprotective activity of cobalt oxide-conjugated hesperidin.
format Article
id doaj-art-c05cc0554e4741be8ef1f11b41db5c86
institution Kabale University
issn 2045-2322
language English
publishDate 2024-12-01
publisher Nature Portfolio
record_format Article
series Scientific Reports
spelling doaj-art-c05cc0554e4741be8ef1f11b41db5c862024-12-29T12:27:00ZengNature PortfolioScientific Reports2045-23222024-12-0114111810.1038/s41598-024-80320-6Amelioration of cognition by hesperidin-conjugated cobalt oxide nanoparticlesAnindita Behera0Bibhanwita Satpathy1Rajesh Kumar Sahoo2Pratap Kumar Sahu3College of Pharmaceutical Sciences, Dayananda Sagar UniversitySchool of Pharmaceutical Sciences, Siksha O Anusandhan Deemed to be UniversityCenter of Biotechnology, Siksha O Anusandhan Deemed to be UniversitySchool of Pharmaceutical Sciences, Siksha O Anusandhan Deemed to be UniversityAbstract Diabetes mellitus is one of the metabolic syndromes that is associated with cognitive deficit, dementia, and Alzheimer’s disease (AD) like pathology due to impaired insulin-signalling in the brain, oxidative stress and mitochondrial dysfunction. Nanotechnology is one of the most promising techniques for targeting the brain. However, the toxicity of metal nanoparticles is one of the biggest challenges to be studied. In this study, cobalt oxide nanoparticles are conjugated to a bioflavonoid, hesperidin, a natural antioxidant. The study is designed to assess the efficacy and safety of the cobalt oxide conjugated hesperidin in the diabetes-induced cognitive deficit rat model. The neuropharmacological behaviour, in-vivo antioxidant status and level of acetylcholinesterase, nitrite, amyloid β, and pro-inflammatory cytokines were determined for cobalt oxide conjugated hesperidin and compared with bare cobalt oxide nanoparticles and hesperidin. The cobalt oxide conjugated hesperidin significantly improved learning and memory in the streptozotocin rat model. However, further studies are required to establish a cellular and molecular mechanism involved in the neuroprotective activity of cobalt oxide-conjugated hesperidin.https://doi.org/10.1038/s41598-024-80320-6Cognitive deficitOxidative stressAcetylcholinesteraseAmyloid βCytokines
spellingShingle Anindita Behera
Bibhanwita Satpathy
Rajesh Kumar Sahoo
Pratap Kumar Sahu
Amelioration of cognition by hesperidin-conjugated cobalt oxide nanoparticles
Scientific Reports
Cognitive deficit
Oxidative stress
Acetylcholinesterase
Amyloid β
Cytokines
title Amelioration of cognition by hesperidin-conjugated cobalt oxide nanoparticles
title_full Amelioration of cognition by hesperidin-conjugated cobalt oxide nanoparticles
title_fullStr Amelioration of cognition by hesperidin-conjugated cobalt oxide nanoparticles
title_full_unstemmed Amelioration of cognition by hesperidin-conjugated cobalt oxide nanoparticles
title_short Amelioration of cognition by hesperidin-conjugated cobalt oxide nanoparticles
title_sort amelioration of cognition by hesperidin conjugated cobalt oxide nanoparticles
topic Cognitive deficit
Oxidative stress
Acetylcholinesterase
Amyloid β
Cytokines
url https://doi.org/10.1038/s41598-024-80320-6
work_keys_str_mv AT aninditabehera ameliorationofcognitionbyhesperidinconjugatedcobaltoxidenanoparticles
AT bibhanwitasatpathy ameliorationofcognitionbyhesperidinconjugatedcobaltoxidenanoparticles
AT rajeshkumarsahoo ameliorationofcognitionbyhesperidinconjugatedcobaltoxidenanoparticles
AT pratapkumarsahu ameliorationofcognitionbyhesperidinconjugatedcobaltoxidenanoparticles