Amelioration of cognition by hesperidin-conjugated cobalt oxide nanoparticles
Abstract Diabetes mellitus is one of the metabolic syndromes that is associated with cognitive deficit, dementia, and Alzheimer’s disease (AD) like pathology due to impaired insulin-signalling in the brain, oxidative stress and mitochondrial dysfunction. Nanotechnology is one of the most promising t...
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Nature Portfolio
2024-12-01
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Online Access: | https://doi.org/10.1038/s41598-024-80320-6 |
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author | Anindita Behera Bibhanwita Satpathy Rajesh Kumar Sahoo Pratap Kumar Sahu |
author_facet | Anindita Behera Bibhanwita Satpathy Rajesh Kumar Sahoo Pratap Kumar Sahu |
author_sort | Anindita Behera |
collection | DOAJ |
description | Abstract Diabetes mellitus is one of the metabolic syndromes that is associated with cognitive deficit, dementia, and Alzheimer’s disease (AD) like pathology due to impaired insulin-signalling in the brain, oxidative stress and mitochondrial dysfunction. Nanotechnology is one of the most promising techniques for targeting the brain. However, the toxicity of metal nanoparticles is one of the biggest challenges to be studied. In this study, cobalt oxide nanoparticles are conjugated to a bioflavonoid, hesperidin, a natural antioxidant. The study is designed to assess the efficacy and safety of the cobalt oxide conjugated hesperidin in the diabetes-induced cognitive deficit rat model. The neuropharmacological behaviour, in-vivo antioxidant status and level of acetylcholinesterase, nitrite, amyloid β, and pro-inflammatory cytokines were determined for cobalt oxide conjugated hesperidin and compared with bare cobalt oxide nanoparticles and hesperidin. The cobalt oxide conjugated hesperidin significantly improved learning and memory in the streptozotocin rat model. However, further studies are required to establish a cellular and molecular mechanism involved in the neuroprotective activity of cobalt oxide-conjugated hesperidin. |
format | Article |
id | doaj-art-c05cc0554e4741be8ef1f11b41db5c86 |
institution | Kabale University |
issn | 2045-2322 |
language | English |
publishDate | 2024-12-01 |
publisher | Nature Portfolio |
record_format | Article |
series | Scientific Reports |
spelling | doaj-art-c05cc0554e4741be8ef1f11b41db5c862024-12-29T12:27:00ZengNature PortfolioScientific Reports2045-23222024-12-0114111810.1038/s41598-024-80320-6Amelioration of cognition by hesperidin-conjugated cobalt oxide nanoparticlesAnindita Behera0Bibhanwita Satpathy1Rajesh Kumar Sahoo2Pratap Kumar Sahu3College of Pharmaceutical Sciences, Dayananda Sagar UniversitySchool of Pharmaceutical Sciences, Siksha O Anusandhan Deemed to be UniversityCenter of Biotechnology, Siksha O Anusandhan Deemed to be UniversitySchool of Pharmaceutical Sciences, Siksha O Anusandhan Deemed to be UniversityAbstract Diabetes mellitus is one of the metabolic syndromes that is associated with cognitive deficit, dementia, and Alzheimer’s disease (AD) like pathology due to impaired insulin-signalling in the brain, oxidative stress and mitochondrial dysfunction. Nanotechnology is one of the most promising techniques for targeting the brain. However, the toxicity of metal nanoparticles is one of the biggest challenges to be studied. In this study, cobalt oxide nanoparticles are conjugated to a bioflavonoid, hesperidin, a natural antioxidant. The study is designed to assess the efficacy and safety of the cobalt oxide conjugated hesperidin in the diabetes-induced cognitive deficit rat model. The neuropharmacological behaviour, in-vivo antioxidant status and level of acetylcholinesterase, nitrite, amyloid β, and pro-inflammatory cytokines were determined for cobalt oxide conjugated hesperidin and compared with bare cobalt oxide nanoparticles and hesperidin. The cobalt oxide conjugated hesperidin significantly improved learning and memory in the streptozotocin rat model. However, further studies are required to establish a cellular and molecular mechanism involved in the neuroprotective activity of cobalt oxide-conjugated hesperidin.https://doi.org/10.1038/s41598-024-80320-6Cognitive deficitOxidative stressAcetylcholinesteraseAmyloid βCytokines |
spellingShingle | Anindita Behera Bibhanwita Satpathy Rajesh Kumar Sahoo Pratap Kumar Sahu Amelioration of cognition by hesperidin-conjugated cobalt oxide nanoparticles Scientific Reports Cognitive deficit Oxidative stress Acetylcholinesterase Amyloid β Cytokines |
title | Amelioration of cognition by hesperidin-conjugated cobalt oxide nanoparticles |
title_full | Amelioration of cognition by hesperidin-conjugated cobalt oxide nanoparticles |
title_fullStr | Amelioration of cognition by hesperidin-conjugated cobalt oxide nanoparticles |
title_full_unstemmed | Amelioration of cognition by hesperidin-conjugated cobalt oxide nanoparticles |
title_short | Amelioration of cognition by hesperidin-conjugated cobalt oxide nanoparticles |
title_sort | amelioration of cognition by hesperidin conjugated cobalt oxide nanoparticles |
topic | Cognitive deficit Oxidative stress Acetylcholinesterase Amyloid β Cytokines |
url | https://doi.org/10.1038/s41598-024-80320-6 |
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