Immobilized protein strategies based on cell membrane chromatography and its application in discovering active and toxic substances in traditional Chinese medicine

Traditional Chinese medicine (TCM) contributes significantly to human health. Owing to the complexity of the ingredients in TCM, it is necessary to conduct basic research on effective substances and identify toxic substances to control the safety of medication. Cell membrane chromatography (CMC) is...

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Main Authors: Yi Shan, Jiayu Lu, Hua Qian, Zhaomin Xia, Xiaoxue Mo, Meidi An, Wen Yang, Siqi Wang, Delu Che, Cheng Wang, Huaizhen He
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Pharmacological Research
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Online Access:http://www.sciencedirect.com/science/article/pii/S1043661824004377
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author Yi Shan
Jiayu Lu
Hua Qian
Zhaomin Xia
Xiaoxue Mo
Meidi An
Wen Yang
Siqi Wang
Delu Che
Cheng Wang
Huaizhen He
author_facet Yi Shan
Jiayu Lu
Hua Qian
Zhaomin Xia
Xiaoxue Mo
Meidi An
Wen Yang
Siqi Wang
Delu Che
Cheng Wang
Huaizhen He
author_sort Yi Shan
collection DOAJ
description Traditional Chinese medicine (TCM) contributes significantly to human health. Owing to the complexity of the ingredients in TCM, it is necessary to conduct basic research on effective substances and identify toxic substances to control the safety of medication. Cell membrane chromatography (CMC) is an important method for identifying target components in complex systems. The cell membrane stationary phase (CMSP) is the core component and key factor in determining the effectiveness of CMC. This review summarizes the development of CMSP with different membrane protein immobilization strategies and the application of CMC in the discovery of active and toxic substances in TCM, with the aim of providing an effective means for the discovery of active ingredients and quality control of TCM.
format Article
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institution Kabale University
issn 1096-1186
language English
publishDate 2024-12-01
publisher Elsevier
record_format Article
series Pharmacological Research
spelling doaj-art-c04f5fbfc3da47f495fa12220e2976932024-12-18T08:47:17ZengElsevierPharmacological Research1096-11862024-12-01210107492Immobilized protein strategies based on cell membrane chromatography and its application in discovering active and toxic substances in traditional Chinese medicineYi Shan0Jiayu Lu1Hua Qian2Zhaomin Xia3Xiaoxue Mo4Meidi An5Wen Yang6Siqi Wang7Delu Che8Cheng Wang9Huaizhen He10School of Pharmacy, Health Science Center, Xi’an Jiaotong University, Xi’an 710061, PR ChinaSchool of Pharmacy, Health Science Center, Xi’an Jiaotong University, Xi’an 710061, PR ChinaDepartment of Cardiology, The First Afffliated Hospital of Xi’an Jiaotong University, Xi’an 710061, PR ChinaSchool of Pharmacy, Health Science Center, Xi’an Jiaotong University, Xi’an 710061, PR ChinaSchool of Pharmacy, Health Science Center, Xi’an Jiaotong University, Xi’an 710061, PR ChinaSchool of Pharmacy, Health Science Center, Xi’an Jiaotong University, Xi’an 710061, PR ChinaSchool of Pharmacy, Health Science Center, Xi’an Jiaotong University, Xi’an 710061, PR ChinaSchool of Pharmacy, Health Science Center, Xi’an Jiaotong University, Xi’an 710061, PR ChinaDepartment of Dermatology, Northwest Hospital, Xi'an Jiaotong University Second Afffliated Hospital, Xi'an 710000, PR ChinaSchool of Pharmacy, Health Science Center, Xi’an Jiaotong University, Xi’an 710061, PR ChinaSchool of Pharmacy, Health Science Center, Xi’an Jiaotong University, Xi’an 710061, PR China; Corresponding author.Traditional Chinese medicine (TCM) contributes significantly to human health. Owing to the complexity of the ingredients in TCM, it is necessary to conduct basic research on effective substances and identify toxic substances to control the safety of medication. Cell membrane chromatography (CMC) is an important method for identifying target components in complex systems. The cell membrane stationary phase (CMSP) is the core component and key factor in determining the effectiveness of CMC. This review summarizes the development of CMSP with different membrane protein immobilization strategies and the application of CMC in the discovery of active and toxic substances in TCM, with the aim of providing an effective means for the discovery of active ingredients and quality control of TCM.http://www.sciencedirect.com/science/article/pii/S1043661824004377Traditional Chinese MedicineCell membrane chromatographyProtein immobilizationActive substancesToxic substances
spellingShingle Yi Shan
Jiayu Lu
Hua Qian
Zhaomin Xia
Xiaoxue Mo
Meidi An
Wen Yang
Siqi Wang
Delu Che
Cheng Wang
Huaizhen He
Immobilized protein strategies based on cell membrane chromatography and its application in discovering active and toxic substances in traditional Chinese medicine
Pharmacological Research
Traditional Chinese Medicine
Cell membrane chromatography
Protein immobilization
Active substances
Toxic substances
title Immobilized protein strategies based on cell membrane chromatography and its application in discovering active and toxic substances in traditional Chinese medicine
title_full Immobilized protein strategies based on cell membrane chromatography and its application in discovering active and toxic substances in traditional Chinese medicine
title_fullStr Immobilized protein strategies based on cell membrane chromatography and its application in discovering active and toxic substances in traditional Chinese medicine
title_full_unstemmed Immobilized protein strategies based on cell membrane chromatography and its application in discovering active and toxic substances in traditional Chinese medicine
title_short Immobilized protein strategies based on cell membrane chromatography and its application in discovering active and toxic substances in traditional Chinese medicine
title_sort immobilized protein strategies based on cell membrane chromatography and its application in discovering active and toxic substances in traditional chinese medicine
topic Traditional Chinese Medicine
Cell membrane chromatography
Protein immobilization
Active substances
Toxic substances
url http://www.sciencedirect.com/science/article/pii/S1043661824004377
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