Immobilized protein strategies based on cell membrane chromatography and its application in discovering active and toxic substances in traditional Chinese medicine

Immobilized protein strategies based on cell membrane chromatography and its application in discovering active and toxic substances in traditional Chinese medicine

Traditional Chinese medicine (TCM) contributes significantly to human health. Owing to the complexity of the ingredients in TCM, it is necessary to conduct basic research on effective substances and identify toxic substances to control the safety of medication. Cell membrane chromatography (CMC) is...

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Bibliographic Details
Main Authors: Yi Shan, Jiayu Lu, Hua Qian, Zhaomin Xia, Xiaoxue Mo, Meidi An, Wen Yang, Siqi Wang, Delu Che, Cheng Wang, Huaizhen He
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Pharmacological Research
Subjects:
Traditional Chinese Medicine
Cell membrane chromatography
Protein immobilization
Active substances
Toxic substances
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661824004377
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Summary:Traditional Chinese medicine (TCM) contributes significantly to human health. Owing to the complexity of the ingredients in TCM, it is necessary to conduct basic research on effective substances and identify toxic substances to control the safety of medication. Cell membrane chromatography (CMC) is an important method for identifying target components in complex systems. The cell membrane stationary phase (CMSP) is the core component and key factor in determining the effectiveness of CMC. This review summarizes the development of CMSP with different membrane protein immobilization strategies and the application of CMC in the discovery of active and toxic substances in TCM, with the aim of providing an effective means for the discovery of active ingredients and quality control of TCM.
ISSN:1096-1186

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