Serum Leucine-Rich Alpha-2 Glycoprotein 1 Levels in Patients with Lipodystrophy Syndromes
Serum concentrations of leucine-rich alpha-2 glycoprotein 1 (LRG1) are elevated in several cardio-metabolic and inflammatory diseases. LRG1 also plays an important role in the development of hepatic steatosis and insulin resistance. In lipodystrophies (LDs), severe cardio-metabolic complications can...
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MDPI AG
2024-11-01
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| Series: | Biomolecules |
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| author | Michelle Krienke Susan Kralisch Leonie Wagner Anke Tönjes Konstanze Miehle |
| author_facet | Michelle Krienke Susan Kralisch Leonie Wagner Anke Tönjes Konstanze Miehle |
| author_sort | Michelle Krienke |
| collection | DOAJ |
| description | Serum concentrations of leucine-rich alpha-2 glycoprotein 1 (LRG1) are elevated in several cardio-metabolic and inflammatory diseases. LRG1 also plays an important role in the development of hepatic steatosis and insulin resistance. In lipodystrophies (LDs), severe cardio-metabolic complications can be observed. The dysregulation of several adipokines plays a significant role in the clinical manifestation of this syndrome. To date, there have been no studies of LRG1 levels in non-HIV-LD patients. We performed a cross-sectional analysis of LRG1 serum levels in 60 patients with non-HIV-associated LD and in 60 age-, sex-, and BMI-matched healthy controls. Furthermore, we investigated the gene expression of <i>Lrg1</i> in a <i>mouse</i> model of generalised LD. No significant difference was found in the median concentration of LRG1 serum levels between LD patients (18.2 ng/L; interquartile range 8.3 ng/L) and healthy controls (17.8 ng/L; interquartile range 11.0 ng/L). LRG1 serum concentrations correlated positively with CRP serum levels (<i>p</i> < 0.001). <i>Lrg1</i> mRNA expression was downregulated in the adipose tissue, whereas in the liver, no difference in <i>Lrg1</i> expression between LD and wild-type <i>mice</i> was detected. In summary, circulating levels of LRG1 are associated with low-grade inflammation but cannot distinguish between patients with LD and controls. |
| format | Article |
| id | doaj-art-c044d0cf6b934f03ad5bb64263bfd5f3 |
| institution | Kabale University |
| issn | 2218-273X |
| language | English |
| publishDate | 2024-11-01 |
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| series | Biomolecules |
| spelling | doaj-art-c044d0cf6b934f03ad5bb64263bfd5f32024-11-26T17:54:27ZengMDPI AGBiomolecules2218-273X2024-11-011411147410.3390/biom14111474Serum Leucine-Rich Alpha-2 Glycoprotein 1 Levels in Patients with Lipodystrophy SyndromesMichelle Krienke0Susan Kralisch1Leonie Wagner2Anke Tönjes3Konstanze Miehle4Medical Department III—Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Liebigstraße 20, 04103 Leipzig, GermanyMedical Department III—Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Liebigstraße 20, 04103 Leipzig, GermanyMedical Department III—Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Liebigstraße 20, 04103 Leipzig, GermanyMedical Department III—Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Liebigstraße 20, 04103 Leipzig, GermanyMedical Department III—Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Liebigstraße 20, 04103 Leipzig, GermanySerum concentrations of leucine-rich alpha-2 glycoprotein 1 (LRG1) are elevated in several cardio-metabolic and inflammatory diseases. LRG1 also plays an important role in the development of hepatic steatosis and insulin resistance. In lipodystrophies (LDs), severe cardio-metabolic complications can be observed. The dysregulation of several adipokines plays a significant role in the clinical manifestation of this syndrome. To date, there have been no studies of LRG1 levels in non-HIV-LD patients. We performed a cross-sectional analysis of LRG1 serum levels in 60 patients with non-HIV-associated LD and in 60 age-, sex-, and BMI-matched healthy controls. Furthermore, we investigated the gene expression of <i>Lrg1</i> in a <i>mouse</i> model of generalised LD. No significant difference was found in the median concentration of LRG1 serum levels between LD patients (18.2 ng/L; interquartile range 8.3 ng/L) and healthy controls (17.8 ng/L; interquartile range 11.0 ng/L). LRG1 serum concentrations correlated positively with CRP serum levels (<i>p</i> < 0.001). <i>Lrg1</i> mRNA expression was downregulated in the adipose tissue, whereas in the liver, no difference in <i>Lrg1</i> expression between LD and wild-type <i>mice</i> was detected. In summary, circulating levels of LRG1 are associated with low-grade inflammation but cannot distinguish between patients with LD and controls.https://www.mdpi.com/2218-273X/14/11/1474adipokinediabetes mellitusinsulin resistanceleucine-rich 2-glycoprotein 1lipodystrophyobesity |
| spellingShingle | Michelle Krienke Susan Kralisch Leonie Wagner Anke Tönjes Konstanze Miehle Serum Leucine-Rich Alpha-2 Glycoprotein 1 Levels in Patients with Lipodystrophy Syndromes Biomolecules adipokine diabetes mellitus insulin resistance leucine-rich 2-glycoprotein 1 lipodystrophy obesity |
| title | Serum Leucine-Rich Alpha-2 Glycoprotein 1 Levels in Patients with Lipodystrophy Syndromes |
| title_full | Serum Leucine-Rich Alpha-2 Glycoprotein 1 Levels in Patients with Lipodystrophy Syndromes |
| title_fullStr | Serum Leucine-Rich Alpha-2 Glycoprotein 1 Levels in Patients with Lipodystrophy Syndromes |
| title_full_unstemmed | Serum Leucine-Rich Alpha-2 Glycoprotein 1 Levels in Patients with Lipodystrophy Syndromes |
| title_short | Serum Leucine-Rich Alpha-2 Glycoprotein 1 Levels in Patients with Lipodystrophy Syndromes |
| title_sort | serum leucine rich alpha 2 glycoprotein 1 levels in patients with lipodystrophy syndromes |
| topic | adipokine diabetes mellitus insulin resistance leucine-rich 2-glycoprotein 1 lipodystrophy obesity |
| url | https://www.mdpi.com/2218-273X/14/11/1474 |
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