A case of karyomegalic interstitial nephritis without FAN1 mutations in the setting of brentuximab, ifosfamide, and carboplatin exposure

A case of karyomegalic interstitial nephritis without FAN1 mutations in the setting of brentuximab, ifosfamide, and carboplatin exposure

Abstract Background Karyomegalic interstitial nephritis (KIN) is a rare renal diagnosis associated with both genetic and medication etiologies. The primary gene associated with KIN is the FAN1 gene which encodes a protein responsible for DNA interstrand repair. Common medication triggers of KIN are...

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Bibliographic Details
Main Authors: Matthew Leong, Tiane Dai, Lili Tong, Cynthia C. Nast
Format: Article
Language:English
Published: BMC 2024-11-01
Series:BMC Nephrology
Subjects:
Karyomegalic interstitial nephritis
Brentuximab
FAN1
Online Access:https://doi.org/10.1186/s12882-024-03689-6
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