A time for sex: circadian regulation of mammalian sexual and reproductive function
The circadian clock regulates physiological and biochemical processes in nearly every species. Sexual and reproductive behaviors are two processes controlled by the circadian timing system. Evidence supporting the importance of proper clock function on fertility comes from several lines of work demo...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2024.1516767/full |
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| author | Sydney Aten Oscar Ramirez-Plascencia Chiara Blake Chiara Blake Gabriel Holder Gabriel Holder Emma Fishbein Emma Fishbein Adam Vieth Adam Vieth Arman Zarghani-Shiraz Arman Zarghani-Shiraz Evan Keister Evan Keister Shivani Howe Shivani Howe Ashley Appo Ashley Appo Beatrice Palmer Carrie E. Mahoney |
| author_facet | Sydney Aten Oscar Ramirez-Plascencia Chiara Blake Chiara Blake Gabriel Holder Gabriel Holder Emma Fishbein Emma Fishbein Adam Vieth Adam Vieth Arman Zarghani-Shiraz Arman Zarghani-Shiraz Evan Keister Evan Keister Shivani Howe Shivani Howe Ashley Appo Ashley Appo Beatrice Palmer Carrie E. Mahoney |
| author_sort | Sydney Aten |
| collection | DOAJ |
| description | The circadian clock regulates physiological and biochemical processes in nearly every species. Sexual and reproductive behaviors are two processes controlled by the circadian timing system. Evidence supporting the importance of proper clock function on fertility comes from several lines of work demonstrating that misalignment of biological rhythms or disrupted function of the body’s master clock, such as occurs from repeated shift work or chronic jet lag, negatively impacts reproduction by interfering with both male and female fertility. Along these lines, dysregulation of clock genes leads to impairments in fertility within mammals, and disruption of circadian clock timing negatively impacts sex hormone levels and semen quality in males, and it leads to ovulatory deficiencies in females. Here, we review the current understanding of the circadian modulation of both male and female reproductive hormones—from animal models to humans. Further, we discuss neural circuits within the hypothalamus that may regulate circadian changes in mammalian sexual behavior and reproduction, and we explore how knowledge of such circuits in animal models may help to improve human sexual function, fertility, and reproduction. |
| format | Article |
| id | doaj-art-c0384faf3adc45f5855df2d50bca03ae |
| institution | Kabale University |
| issn | 1662-453X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj-art-c0384faf3adc45f5855df2d50bca03ae2025-01-06T06:59:09ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2025-01-011810.3389/fnins.2024.15167671516767A time for sex: circadian regulation of mammalian sexual and reproductive functionSydney Aten0Oscar Ramirez-Plascencia1Chiara Blake2Chiara Blake3Gabriel Holder4Gabriel Holder5Emma Fishbein6Emma Fishbein7Adam Vieth8Adam Vieth9Arman Zarghani-Shiraz10Arman Zarghani-Shiraz11Evan Keister12Evan Keister13Shivani Howe14Shivani Howe15Ashley Appo16Ashley Appo17Beatrice Palmer18Carrie E. Mahoney19Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United StatesDepartment of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United StatesDepartment of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United StatesBehavioral Neuroscience, College of Science, Northeastern University, Boston, MA, United StatesDepartment of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United StatesBehavioral Neuroscience, College of Science, Northeastern University, Boston, MA, United StatesDepartment of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United StatesDepartment of Biology, School of Arts and Sciences, Tufts University, Medford, MA, United StatesDepartment of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United StatesBehavioral Neuroscience, College of Science, Northeastern University, Boston, MA, United StatesDepartment of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United StatesDepartment of Psychological and Brain Sciences, College of Arts and Sciences, Boston University, Boston, MA, United StatesDepartment of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United StatesBehavioral Neuroscience, College of Science, Northeastern University, Boston, MA, United StatesDepartment of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United StatesBehavioral Neuroscience, College of Science, Northeastern University, Boston, MA, United StatesDepartment of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United StatesBehavioral Neuroscience, College of Science, Northeastern University, Boston, MA, United StatesDepartment of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United StatesDepartment of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United StatesThe circadian clock regulates physiological and biochemical processes in nearly every species. Sexual and reproductive behaviors are two processes controlled by the circadian timing system. Evidence supporting the importance of proper clock function on fertility comes from several lines of work demonstrating that misalignment of biological rhythms or disrupted function of the body’s master clock, such as occurs from repeated shift work or chronic jet lag, negatively impacts reproduction by interfering with both male and female fertility. Along these lines, dysregulation of clock genes leads to impairments in fertility within mammals, and disruption of circadian clock timing negatively impacts sex hormone levels and semen quality in males, and it leads to ovulatory deficiencies in females. Here, we review the current understanding of the circadian modulation of both male and female reproductive hormones—from animal models to humans. Further, we discuss neural circuits within the hypothalamus that may regulate circadian changes in mammalian sexual behavior and reproduction, and we explore how knowledge of such circuits in animal models may help to improve human sexual function, fertility, and reproduction.https://www.frontiersin.org/articles/10.3389/fnins.2024.1516767/fullcircadiansexreproductionmammalianclock timingfertility |
| spellingShingle | Sydney Aten Oscar Ramirez-Plascencia Chiara Blake Chiara Blake Gabriel Holder Gabriel Holder Emma Fishbein Emma Fishbein Adam Vieth Adam Vieth Arman Zarghani-Shiraz Arman Zarghani-Shiraz Evan Keister Evan Keister Shivani Howe Shivani Howe Ashley Appo Ashley Appo Beatrice Palmer Carrie E. Mahoney A time for sex: circadian regulation of mammalian sexual and reproductive function Frontiers in Neuroscience circadian sex reproduction mammalian clock timing fertility |
| title | A time for sex: circadian regulation of mammalian sexual and reproductive function |
| title_full | A time for sex: circadian regulation of mammalian sexual and reproductive function |
| title_fullStr | A time for sex: circadian regulation of mammalian sexual and reproductive function |
| title_full_unstemmed | A time for sex: circadian regulation of mammalian sexual and reproductive function |
| title_short | A time for sex: circadian regulation of mammalian sexual and reproductive function |
| title_sort | time for sex circadian regulation of mammalian sexual and reproductive function |
| topic | circadian sex reproduction mammalian clock timing fertility |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2024.1516767/full |
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