Advancements in surface modification strategies of vascular grafts to improve biocompatibility and tissue integration

Improving the performance of blood-contacting medical implants is a global health necessity aimed at reducing mortality and morbidity in patients with cardiovascular diseases. Surface modification of the biomaterials from which the vascular grafts are constructed has been used to reduce the risk of...

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Main Authors: Noor Abu Jarad, Andrew Chami, Jeffrey I. Weitz, Tohid F. Didar
Format: Article
Language:English
Published: Open Exploration Publishing Inc. 2024-09-01
Series:Exploration of BioMat-X
Subjects:
Online Access:https://www.explorationpub.com/uploads/Article/A101318/101318.pdf
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author Noor Abu Jarad
Andrew Chami
Jeffrey I. Weitz
Tohid F. Didar
author_facet Noor Abu Jarad
Andrew Chami
Jeffrey I. Weitz
Tohid F. Didar
author_sort Noor Abu Jarad
collection DOAJ
description Improving the performance of blood-contacting medical implants is a global health necessity aimed at reducing mortality and morbidity in patients with cardiovascular diseases. Surface modification of the biomaterials from which the vascular grafts are constructed has been used to reduce the risk of complications such as thrombosis and infection. Herein with a focus on vascular tissue engineering, we provided an overview of (a) fundamental hemodynamic considerations for blood-contacting biomaterials, (b) surface modification strategies to attenuate nonspecific adhesion of proteins, improve hemocompatibility, and induce the formation of a confluent endothelial lining, and (c) the guidelines for the clinical development of surface modified biomaterials.
format Article
id doaj-art-c00d741aee1a45d09dc032a2d0ef1831
institution Kabale University
issn 2996-9476
language English
publishDate 2024-09-01
publisher Open Exploration Publishing Inc.
record_format Article
series Exploration of BioMat-X
spelling doaj-art-c00d741aee1a45d09dc032a2d0ef18312025-08-20T03:51:19ZengOpen Exploration Publishing Inc.Exploration of BioMat-X2996-94762024-09-011524126510.37349/ebmx.2024.00018Advancements in surface modification strategies of vascular grafts to improve biocompatibility and tissue integrationNoor Abu Jarad0Andrew Chami1Jeffrey I. Weitz2https://orcid.org/0000-0002-1092-7550Tohid F. Didar3https://orcid.org/0000-0002-8757-8002School of Biomedical Engineering, McMaster University, Hamilton, ON L8S 4K1, CanadaFaculty of Health Sciences, McMaster University, Hamilton, ON L8S 4K1, CanadaDepartment of Medicine, McMaster University, Hamilton, ON L8L 2X2, Canada; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8L 2X2, Canada; Thrombosis & Atherosclerosis Research Institute, McMaster University, Hamilton, ON L8L 2X2, CanadaSchool of Biomedical Engineering, McMaster University, Hamilton, ON L8S 4K1, Canada; Faculty of Health Sciences, McMaster University, Hamilton, ON L8S 4K1, CanadaImproving the performance of blood-contacting medical implants is a global health necessity aimed at reducing mortality and morbidity in patients with cardiovascular diseases. Surface modification of the biomaterials from which the vascular grafts are constructed has been used to reduce the risk of complications such as thrombosis and infection. Herein with a focus on vascular tissue engineering, we provided an overview of (a) fundamental hemodynamic considerations for blood-contacting biomaterials, (b) surface modification strategies to attenuate nonspecific adhesion of proteins, improve hemocompatibility, and induce the formation of a confluent endothelial lining, and (c) the guidelines for the clinical development of surface modified biomaterials.https://www.explorationpub.com/uploads/Article/A101318/101318.pdfblood-contacting implantsthrombogenicityhemocompatibilitysurface coatingslubricant-infused coatings
spellingShingle Noor Abu Jarad
Andrew Chami
Jeffrey I. Weitz
Tohid F. Didar
Advancements in surface modification strategies of vascular grafts to improve biocompatibility and tissue integration
Exploration of BioMat-X
blood-contacting implants
thrombogenicity
hemocompatibility
surface coatings
lubricant-infused coatings
title Advancements in surface modification strategies of vascular grafts to improve biocompatibility and tissue integration
title_full Advancements in surface modification strategies of vascular grafts to improve biocompatibility and tissue integration
title_fullStr Advancements in surface modification strategies of vascular grafts to improve biocompatibility and tissue integration
title_full_unstemmed Advancements in surface modification strategies of vascular grafts to improve biocompatibility and tissue integration
title_short Advancements in surface modification strategies of vascular grafts to improve biocompatibility and tissue integration
title_sort advancements in surface modification strategies of vascular grafts to improve biocompatibility and tissue integration
topic blood-contacting implants
thrombogenicity
hemocompatibility
surface coatings
lubricant-infused coatings
url https://www.explorationpub.com/uploads/Article/A101318/101318.pdf
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AT jeffreyiweitz advancementsinsurfacemodificationstrategiesofvasculargraftstoimprovebiocompatibilityandtissueintegration
AT tohidfdidar advancementsinsurfacemodificationstrategiesofvasculargraftstoimprovebiocompatibilityandtissueintegration