Intracranial Blood Flow Velocity in Patients with β-Thalassemia Intermedia Using Transcranial Doppler Sonography: A Case-Control Study
Introduction. Patients with β-thalassemia intermedia have a higher incidence of thromboembolic events compared to the general population. Previous studies have shown that patients with sickle cell disease, who are also prone to ischemic events, have higher intracranial arterial blood flow velocities...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Anemia |
| Online Access: | http://dx.doi.org/10.1155/2012/798296 |
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| author | Nahid Ashjazadeh Sajad Emami Peyman Petramfar Ehsan Yaghoubi Mehran Karimi |
| author_facet | Nahid Ashjazadeh Sajad Emami Peyman Petramfar Ehsan Yaghoubi Mehran Karimi |
| author_sort | Nahid Ashjazadeh |
| collection | DOAJ |
| description | Introduction. Patients with β-thalassemia intermedia have a higher incidence of thromboembolic events compared to the general population. Previous studies have shown that patients with sickle cell disease, who are also prone to ischemic events, have higher intracranial arterial blood flow velocities measured by transcranial Doppler sonography (TCD). The aim of this study is to evaluate intracranial arterial flow velocities in patients with β-thalassemia intermedia and compare the results with those found in healthy subjects. Methods. Sixty-four patients with β-thalassemia intermedia and 30 healthy subjects underwent transcranial Doppler sonography. Results. Significantly higher flow velocities were found in intracranial arteries of patients compared to controls (P=0.001). Previously splenectomized patients with thrombocytosis showed higher flow velocities than nonsplenectomized patients without thrombosis. Conclusion. The increased flow velocities in patients with β-thalassemia intermedia may point to a higher risk of ischemic events. Preventive measures such as blood transfusion or antiplatelet treatment may be beneficial in these patients. |
| format | Article |
| id | doaj-art-c005055044f342ee89d0e8d1a7d3fea9 |
| institution | Kabale University |
| issn | 2090-1267 2090-1275 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Anemia |
| spelling | doaj-art-c005055044f342ee89d0e8d1a7d3fea92025-02-03T05:53:00ZengWileyAnemia2090-12672090-12752012-01-01201210.1155/2012/798296798296Intracranial Blood Flow Velocity in Patients with β-Thalassemia Intermedia Using Transcranial Doppler Sonography: A Case-Control StudyNahid Ashjazadeh0Sajad Emami1Peyman Petramfar2Ehsan Yaghoubi3Mehran Karimi4Shiraz Neuroscience Research Center, Department of Neurology, Shiraz University of Medical Sciences, Shiraz, IranShiraz Neuroscience Research Center, Department of Neurology, Shiraz University of Medical Sciences, Shiraz, IranShiraz Neuroscience Research Center, Department of Neurology, Shiraz University of Medical Sciences, Shiraz, IranShiraz Neuroscience Research Center, Department of Neurology, Shiraz University of Medical Sciences, Shiraz, IranHematology Research Center, Shiraz University of Medical Sciences, Shiraz, IranIntroduction. Patients with β-thalassemia intermedia have a higher incidence of thromboembolic events compared to the general population. Previous studies have shown that patients with sickle cell disease, who are also prone to ischemic events, have higher intracranial arterial blood flow velocities measured by transcranial Doppler sonography (TCD). The aim of this study is to evaluate intracranial arterial flow velocities in patients with β-thalassemia intermedia and compare the results with those found in healthy subjects. Methods. Sixty-four patients with β-thalassemia intermedia and 30 healthy subjects underwent transcranial Doppler sonography. Results. Significantly higher flow velocities were found in intracranial arteries of patients compared to controls (P=0.001). Previously splenectomized patients with thrombocytosis showed higher flow velocities than nonsplenectomized patients without thrombosis. Conclusion. The increased flow velocities in patients with β-thalassemia intermedia may point to a higher risk of ischemic events. Preventive measures such as blood transfusion or antiplatelet treatment may be beneficial in these patients.http://dx.doi.org/10.1155/2012/798296 |
| spellingShingle | Nahid Ashjazadeh Sajad Emami Peyman Petramfar Ehsan Yaghoubi Mehran Karimi Intracranial Blood Flow Velocity in Patients with β-Thalassemia Intermedia Using Transcranial Doppler Sonography: A Case-Control Study Anemia |
| title | Intracranial Blood Flow Velocity in Patients with β-Thalassemia Intermedia Using Transcranial Doppler Sonography: A Case-Control Study |
| title_full | Intracranial Blood Flow Velocity in Patients with β-Thalassemia Intermedia Using Transcranial Doppler Sonography: A Case-Control Study |
| title_fullStr | Intracranial Blood Flow Velocity in Patients with β-Thalassemia Intermedia Using Transcranial Doppler Sonography: A Case-Control Study |
| title_full_unstemmed | Intracranial Blood Flow Velocity in Patients with β-Thalassemia Intermedia Using Transcranial Doppler Sonography: A Case-Control Study |
| title_short | Intracranial Blood Flow Velocity in Patients with β-Thalassemia Intermedia Using Transcranial Doppler Sonography: A Case-Control Study |
| title_sort | intracranial blood flow velocity in patients with β thalassemia intermedia using transcranial doppler sonography a case control study |
| url | http://dx.doi.org/10.1155/2012/798296 |
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