The Potential of Secondary Metabolites in Medicinal Plants as Anti–Quorum Sensing in Biofilms: A Comprehensive Review
The formation of biofilms occurs due to a group of bacteria gathering together. The increasing of cell density will stimulate chemical signals for bacteria to communicate through quorum sensing system. Quorum sensing plays a role for competition, virulence, resistance, and pathogenesis. Quorum sensi...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-01-01
|
| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/joch/8838140 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841542628928126976 |
|---|---|
| author | Salsabila Aqila Putri Euis Julaeha Natsuko Kagawa Dikdik Kurnia |
| author_facet | Salsabila Aqila Putri Euis Julaeha Natsuko Kagawa Dikdik Kurnia |
| author_sort | Salsabila Aqila Putri |
| collection | DOAJ |
| description | The formation of biofilms occurs due to a group of bacteria gathering together. The increasing of cell density will stimulate chemical signals for bacteria to communicate through quorum sensing system. Quorum sensing plays a role for competition, virulence, resistance, and pathogenesis. Quorum sensing produces signaling response called as autoinducers. Gram-negative bacteria produce N-acyl-L-homoserine lactones as autoinducer, while quorum sensing in Gram-positive bacteria produces autoinducing peptides. By looking at quorum sensing responses in bacterial pathogenesis and resistance, the study of natural antibiotic agents became a particular concern for researchers. This review summarizes the study of quorum sensing systems acting on Gram-positive and Gram-negative bacteria, the role of quorum sensing on biofilm formation by pathogenic bacteria, and the potential use of medicinal plants as natural anti–quorum sensing agents reviewed in vitro and in silico. The use of extracts from leaves, fruits, flowers, stems, and isolated compounds of some types of plants and essential oils has been successfully tested to have anti–quorum sensing activity. |
| format | Article |
| id | doaj-art-c0024e54e4164a1289d1988c903914f1 |
| institution | Kabale University |
| issn | 2090-9071 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-c0024e54e4164a1289d1988c903914f12025-01-14T00:00:02ZengWileyJournal of Chemistry2090-90712025-01-01202510.1155/joch/8838140The Potential of Secondary Metabolites in Medicinal Plants as Anti–Quorum Sensing in Biofilms: A Comprehensive ReviewSalsabila Aqila Putri0Euis Julaeha1Natsuko Kagawa2Dikdik Kurnia3Department of ChemistryDepartment of ChemistryGraduate School of HorticultureDepartment of ChemistryThe formation of biofilms occurs due to a group of bacteria gathering together. The increasing of cell density will stimulate chemical signals for bacteria to communicate through quorum sensing system. Quorum sensing plays a role for competition, virulence, resistance, and pathogenesis. Quorum sensing produces signaling response called as autoinducers. Gram-negative bacteria produce N-acyl-L-homoserine lactones as autoinducer, while quorum sensing in Gram-positive bacteria produces autoinducing peptides. By looking at quorum sensing responses in bacterial pathogenesis and resistance, the study of natural antibiotic agents became a particular concern for researchers. This review summarizes the study of quorum sensing systems acting on Gram-positive and Gram-negative bacteria, the role of quorum sensing on biofilm formation by pathogenic bacteria, and the potential use of medicinal plants as natural anti–quorum sensing agents reviewed in vitro and in silico. The use of extracts from leaves, fruits, flowers, stems, and isolated compounds of some types of plants and essential oils has been successfully tested to have anti–quorum sensing activity.http://dx.doi.org/10.1155/joch/8838140 |
| spellingShingle | Salsabila Aqila Putri Euis Julaeha Natsuko Kagawa Dikdik Kurnia The Potential of Secondary Metabolites in Medicinal Plants as Anti–Quorum Sensing in Biofilms: A Comprehensive Review Journal of Chemistry |
| title | The Potential of Secondary Metabolites in Medicinal Plants as Anti–Quorum Sensing in Biofilms: A Comprehensive Review |
| title_full | The Potential of Secondary Metabolites in Medicinal Plants as Anti–Quorum Sensing in Biofilms: A Comprehensive Review |
| title_fullStr | The Potential of Secondary Metabolites in Medicinal Plants as Anti–Quorum Sensing in Biofilms: A Comprehensive Review |
| title_full_unstemmed | The Potential of Secondary Metabolites in Medicinal Plants as Anti–Quorum Sensing in Biofilms: A Comprehensive Review |
| title_short | The Potential of Secondary Metabolites in Medicinal Plants as Anti–Quorum Sensing in Biofilms: A Comprehensive Review |
| title_sort | potential of secondary metabolites in medicinal plants as anti quorum sensing in biofilms a comprehensive review |
| url | http://dx.doi.org/10.1155/joch/8838140 |
| work_keys_str_mv | AT salsabilaaqilaputri thepotentialofsecondarymetabolitesinmedicinalplantsasantiquorumsensinginbiofilmsacomprehensivereview AT euisjulaeha thepotentialofsecondarymetabolitesinmedicinalplantsasantiquorumsensinginbiofilmsacomprehensivereview AT natsukokagawa thepotentialofsecondarymetabolitesinmedicinalplantsasantiquorumsensinginbiofilmsacomprehensivereview AT dikdikkurnia thepotentialofsecondarymetabolitesinmedicinalplantsasantiquorumsensinginbiofilmsacomprehensivereview AT salsabilaaqilaputri potentialofsecondarymetabolitesinmedicinalplantsasantiquorumsensinginbiofilmsacomprehensivereview AT euisjulaeha potentialofsecondarymetabolitesinmedicinalplantsasantiquorumsensinginbiofilmsacomprehensivereview AT natsukokagawa potentialofsecondarymetabolitesinmedicinalplantsasantiquorumsensinginbiofilmsacomprehensivereview AT dikdikkurnia potentialofsecondarymetabolitesinmedicinalplantsasantiquorumsensinginbiofilmsacomprehensivereview |