Effect of Electroacupuncture at Changqiang Acupoint on Learning and Memory Ability and Hippocampal CA1 Apoptosis in Rats with Vascular Dementia
Objective:To observe the effect of electro-acupuncture (EA) at Changqiang (GV1) acupoint on the learning and memory ability and hippocampal CA1 cellular apoptosis in rats with vascular dementia (VD).Methods:Sixty male SD rats according to the Morris water maze test were divided into three groups: 9...
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Editorial Office of Rehabilitation Medicine
2016-10-01
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| Series: | 康复学报 |
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| Online Access: | http://kfxb.publish.founderss.cn/thesisDetails#10.3724/SP.J.1329.2016.05033 |
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| author | Ke'ai CHEN Ping YU Jie CHEN Lianhong HUANG Wei XU |
| author_facet | Ke'ai CHEN Ping YU Jie CHEN Lianhong HUANG Wei XU |
| author_sort | Ke'ai CHEN |
| collection | DOAJ |
| description | Objective:To observe the effect of electro-acupuncture (EA) at Changqiang (GV1) acupoint on the learning and memory ability and hippocampal CA1 cellular apoptosis in rats with vascular dementia (VD).Methods:Sixty male SD rats according to the Morris water maze test were divided into three groups: 9 rats for blank control group, 9 rats for sham-operated group and 42 rats for surgical control group. Rats of VD models were established by 2 vessels obstruction (2-VO), 27 rats were selected from the surgical control group and divided into three groups: 9 rats for model group, 9 rats for EA treatment group and rest 9 rats for the non-acupoint EA control group. After the treatment, the water maze test and the TUNEL test were examined.Results:Compared with the model group, the escape latent period and the CA1 apoptosis of the blank control group and the EA treatment group were apparently shorter (<italic>P</italic><0.05), and the times of crossing the platform were significantly increased (<italic>P</italic><0.05). A positive correlation between CA1 apoptosis and latent period was identified (<italic>P</italic><0.05), a negative correlation between apoptosis and the times of crossing was identified (<italic>P</italic><0.05).Conclusion:EA at Changqiang acupoint may improve the learning and memorizing ability and restrain the apoptosis of hippocampal CA1 region of VD rats, and association of the ability and apoptosis is positive. |
| format | Article |
| id | doaj-art-bff038497b8f42d18641e73d75e9c52b |
| institution | Kabale University |
| issn | 2096-0328 |
| language | English |
| publishDate | 2016-10-01 |
| publisher | Editorial Office of Rehabilitation Medicine |
| record_format | Article |
| series | 康复学报 |
| spelling | doaj-art-bff038497b8f42d18641e73d75e9c52b2025-01-14T10:06:06ZengEditorial Office of Rehabilitation Medicine康复学报2096-03282016-10-0126333623096399Effect of Electroacupuncture at Changqiang Acupoint on Learning and Memory Ability and Hippocampal CA1 Apoptosis in Rats with Vascular DementiaKe'ai CHENPing YUJie CHENLianhong HUANGWei XUObjective:To observe the effect of electro-acupuncture (EA) at Changqiang (GV1) acupoint on the learning and memory ability and hippocampal CA1 cellular apoptosis in rats with vascular dementia (VD).Methods:Sixty male SD rats according to the Morris water maze test were divided into three groups: 9 rats for blank control group, 9 rats for sham-operated group and 42 rats for surgical control group. Rats of VD models were established by 2 vessels obstruction (2-VO), 27 rats were selected from the surgical control group and divided into three groups: 9 rats for model group, 9 rats for EA treatment group and rest 9 rats for the non-acupoint EA control group. After the treatment, the water maze test and the TUNEL test were examined.Results:Compared with the model group, the escape latent period and the CA1 apoptosis of the blank control group and the EA treatment group were apparently shorter (<italic>P</italic><0.05), and the times of crossing the platform were significantly increased (<italic>P</italic><0.05). A positive correlation between CA1 apoptosis and latent period was identified (<italic>P</italic><0.05), a negative correlation between apoptosis and the times of crossing was identified (<italic>P</italic><0.05).Conclusion:EA at Changqiang acupoint may improve the learning and memorizing ability and restrain the apoptosis of hippocampal CA1 region of VD rats, and association of the ability and apoptosis is positive.http://kfxb.publish.founderss.cn/thesisDetails#10.3724/SP.J.1329.2016.05033vascular dementiaChangqiang acupointhippocampuslearning and memory abilityapoptosis |
| spellingShingle | Ke'ai CHEN Ping YU Jie CHEN Lianhong HUANG Wei XU Effect of Electroacupuncture at Changqiang Acupoint on Learning and Memory Ability and Hippocampal CA1 Apoptosis in Rats with Vascular Dementia 康复学报 vascular dementia Changqiang acupoint hippocampus learning and memory ability apoptosis |
| title | Effect of Electroacupuncture at Changqiang Acupoint on Learning and Memory Ability and Hippocampal CA1 Apoptosis in Rats with Vascular Dementia |
| title_full | Effect of Electroacupuncture at Changqiang Acupoint on Learning and Memory Ability and Hippocampal CA1 Apoptosis in Rats with Vascular Dementia |
| title_fullStr | Effect of Electroacupuncture at Changqiang Acupoint on Learning and Memory Ability and Hippocampal CA1 Apoptosis in Rats with Vascular Dementia |
| title_full_unstemmed | Effect of Electroacupuncture at Changqiang Acupoint on Learning and Memory Ability and Hippocampal CA1 Apoptosis in Rats with Vascular Dementia |
| title_short | Effect of Electroacupuncture at Changqiang Acupoint on Learning and Memory Ability and Hippocampal CA1 Apoptosis in Rats with Vascular Dementia |
| title_sort | effect of electroacupuncture at changqiang acupoint on learning and memory ability and hippocampal ca1 apoptosis in rats with vascular dementia |
| topic | vascular dementia Changqiang acupoint hippocampus learning and memory ability apoptosis |
| url | http://kfxb.publish.founderss.cn/thesisDetails#10.3724/SP.J.1329.2016.05033 |
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