Effect of Electroacupuncture at Changqiang Acupoint on Learning and Memory Ability and Hippocampal CA1 Apoptosis in Rats with Vascular Dementia
Objective:To observe the effect of electro-acupuncture (EA) at Changqiang (GV1) acupoint on the learning and memory ability and hippocampal CA1 cellular apoptosis in rats with vascular dementia (VD).Methods:Sixty male SD rats according to the Morris water maze test were divided into three groups: 9...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Editorial Office of Rehabilitation Medicine
2016-10-01
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| Series: | 康复学报 |
| Subjects: | |
| Online Access: | http://kfxb.publish.founderss.cn/thesisDetails#10.3724/SP.J.1329.2016.05033 |
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| Summary: | Objective:To observe the effect of electro-acupuncture (EA) at Changqiang (GV1) acupoint on the learning and memory ability and hippocampal CA1 cellular apoptosis in rats with vascular dementia (VD).Methods:Sixty male SD rats according to the Morris water maze test were divided into three groups: 9 rats for blank control group, 9 rats for sham-operated group and 42 rats for surgical control group. Rats of VD models were established by 2 vessels obstruction (2-VO), 27 rats were selected from the surgical control group and divided into three groups: 9 rats for model group, 9 rats for EA treatment group and rest 9 rats for the non-acupoint EA control group. After the treatment, the water maze test and the TUNEL test were examined.Results:Compared with the model group, the escape latent period and the CA1 apoptosis of the blank control group and the EA treatment group were apparently shorter (<italic>P</italic><0.05), and the times of crossing the platform were significantly increased (<italic>P</italic><0.05). A positive correlation between CA1 apoptosis and latent period was identified (<italic>P</italic><0.05), a negative correlation between apoptosis and the times of crossing was identified (<italic>P</italic><0.05).Conclusion:EA at Changqiang acupoint may improve the learning and memorizing ability and restrain the apoptosis of hippocampal CA1 region of VD rats, and association of the ability and apoptosis is positive. |
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| ISSN: | 2096-0328 |