A scoping review on the importance of vaccination strategies targeting skin imprinting for arthropod-borne diseases
Abstract Tissue-resident memory T (TRM) cells in the skin play a critical role in early immune defense against pathogens entering via breaches such as arthropod bites. However, their specific induction through immunization strategies remains underexplored. We performed a scoping review following PRI...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-07-01
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| Series: | npj Vaccines |
| Online Access: | https://doi.org/10.1038/s41541-025-01189-8 |
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| author | Janne Wouters Aliana Saenz de la Torre Leal Wim Adriaensen |
| author_facet | Janne Wouters Aliana Saenz de la Torre Leal Wim Adriaensen |
| author_sort | Janne Wouters |
| collection | DOAJ |
| description | Abstract Tissue-resident memory T (TRM) cells in the skin play a critical role in early immune defense against pathogens entering via breaches such as arthropod bites. However, their specific induction through immunization strategies remains underexplored. We performed a scoping review following PRISMA guidelines to assess vaccination strategies capable of inducing skin TRM cells. Intradermal and skin scarification routes consistently induced skin TRM cells with 94–100% success rates, while viral vector, DNA-based, and live-attenuated vaccines were the most effective platforms, particularly when combined with adjuvants promoting local inflammation. CD69 and CD103 were the most frequently employed markers, despite significant methodological heterogeneity. Vaccine-induced TRM cells were shown to disseminate throughout the skin and confer durable protection, independent of circulating T cells. However, evidence is largely restricted to preclinical studies, underscoring the need for standardization of TRM cell identification and expanded human studies to translate these findings into clinical practice. |
| format | Article |
| id | doaj-art-bfecd2f601c94ce5ac6a9363a65db4e6 |
| institution | Kabale University |
| issn | 2059-0105 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Vaccines |
| spelling | doaj-art-bfecd2f601c94ce5ac6a9363a65db4e62025-08-20T04:01:24ZengNature Portfolionpj Vaccines2059-01052025-07-0110111510.1038/s41541-025-01189-8A scoping review on the importance of vaccination strategies targeting skin imprinting for arthropod-borne diseasesJanne Wouters0Aliana Saenz de la Torre Leal1Wim Adriaensen2Clinical Immunology Unit, Department of Clinical Sciences, Institute of Tropical MedicineClinical Immunology Unit, Department of Clinical Sciences, Institute of Tropical MedicineClinical Immunology Unit, Department of Clinical Sciences, Institute of Tropical MedicineAbstract Tissue-resident memory T (TRM) cells in the skin play a critical role in early immune defense against pathogens entering via breaches such as arthropod bites. However, their specific induction through immunization strategies remains underexplored. We performed a scoping review following PRISMA guidelines to assess vaccination strategies capable of inducing skin TRM cells. Intradermal and skin scarification routes consistently induced skin TRM cells with 94–100% success rates, while viral vector, DNA-based, and live-attenuated vaccines were the most effective platforms, particularly when combined with adjuvants promoting local inflammation. CD69 and CD103 were the most frequently employed markers, despite significant methodological heterogeneity. Vaccine-induced TRM cells were shown to disseminate throughout the skin and confer durable protection, independent of circulating T cells. However, evidence is largely restricted to preclinical studies, underscoring the need for standardization of TRM cell identification and expanded human studies to translate these findings into clinical practice.https://doi.org/10.1038/s41541-025-01189-8 |
| spellingShingle | Janne Wouters Aliana Saenz de la Torre Leal Wim Adriaensen A scoping review on the importance of vaccination strategies targeting skin imprinting for arthropod-borne diseases npj Vaccines |
| title | A scoping review on the importance of vaccination strategies targeting skin imprinting for arthropod-borne diseases |
| title_full | A scoping review on the importance of vaccination strategies targeting skin imprinting for arthropod-borne diseases |
| title_fullStr | A scoping review on the importance of vaccination strategies targeting skin imprinting for arthropod-borne diseases |
| title_full_unstemmed | A scoping review on the importance of vaccination strategies targeting skin imprinting for arthropod-borne diseases |
| title_short | A scoping review on the importance of vaccination strategies targeting skin imprinting for arthropod-borne diseases |
| title_sort | scoping review on the importance of vaccination strategies targeting skin imprinting for arthropod borne diseases |
| url | https://doi.org/10.1038/s41541-025-01189-8 |
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