SMAC-armed oncolytic virotherapy enhances the anticancer activity of PD1 blockade by modulating PANoptosis

SMAC-armed oncolytic virotherapy enhances the anticancer activity of PD1 blockade by modulating PANoptosis

Abstract Background Oncolytic viruses (OVs) are increasingly recognized as promising tools for cancer therapy, as they selectively infect and destroy tumor cells while leaving healthy cells unharmed. Despite considerable progress, the limited therapeutic efficacy of OV-based virotherapy continues to...

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Bibliographic Details
Main Authors: Fanghui Chen, Liwei Lang, Jianqiang Yang, Fan Yang, Sijia Tang, Zhenzhen Fu, Nabil F. Saba, Ming Luo, Yong Teng
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Biomarker Research
Subjects:
VSV-S
Head and neck cancer
PANoptosis
Immunotherapy
Antitumor immunity
Online Access:https://doi.org/10.1186/s40364-025-00726-w
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