Hepatitis B virus surface antigen drives T cell immunity through non-canonical antigen presentation in mice

Hepatitis B virus surface antigen drives T cell immunity through non-canonical antigen presentation in mice

Abstract Hepatitis B virus (HBV) exclusively infects hepatocytes and produces large amounts of subviral particles containing its surface antigen (HBsAg). T cell immunity is crucial for controlling and clearing HBV infection. However, the intercellular processes underlying HBsAg presentation to T cel...

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Main Authors: Xiaofang Li, Wenxuan Sun, Xiaolan Xu, Qirong Jiang, Yuheng Shi, Huixi Zhang, Weien Yu, Bisheng Shi, Simin Wan, Jiangxia Liu, Wuhui Song, Jiming Zhang, Zhenghong Yuan, Jianhua Li
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59985-8
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https://doi.org/10.1038/s41467-025-59985-8

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