Identity and stability assessment of BCG vaccine by multiplex PCR

Identity and stability assessment of BCG vaccine by multiplex PCR

Multiplex polymerase chain reaction method was used to assess the stability of 7 seed lots of a substrain Mycobacterium bovis BCG-1, Russia, used for the manufacture of BCG vaccine since 1948 till present. For performng PCR we used primers, matching 5 parts of the RD field and 1part of repeating ele...

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Bibliographic Details
Main Authors: D. T. Levi, Yu. I. Obukhov, N. V. Aleksandrova, R. A. Volkova, E. V. Elbert, M. V. Alvarez Figeroa, A. V. Prokopenko, R. I. Ludanniy
Format: Article
Language:Russian
Published: Ministry of Health of the Russian Federation. Federal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products» 2018-02-01
Series:Биопрепараты: Профилактика, диагностика, лечение
Subjects:
посевная серия
мультиплексная полимеразная реакция
субштаммы бцж
стабильнось
подлинность
seed lot
multiplex polymerase reaction
bcg substrains
stability
identity
Online Access:https://www.biopreparations.ru/jour/article/view/41
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