Identification of a novel nuclease activity in human DDX49 helicase

Identification of a novel nuclease activity in human DDX49 helicase

Human DDX49 is an emerging target in cancer progression and retroviral diseases through its essential roles in nucleolar RNA processing. Here, we identify nuclease activity of human DDX49, which requires active site aspartate residues within a conserved region of metazoan DDX49s that is absent from...

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Bibliographic Details
Main Authors: Ashley J. Parkes, Sabesan Anandavijayan, Anna Lou-Hing, Olivia Downs, Tom Killelea, Louise Martin, Fiorela Kapllanaj, Edward L. Bolt
Format: Article
Language:English
Published: The Royal Society 2024-12-01
Series:Royal Society Open Science
Subjects:
novel
nuclease
activity
human
DDX49
helicase
Online Access:https://royalsocietypublishing.org/doi/10.1098/rsos.241891
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