The association between the genetic structures of commonly incompatible plasmids in Gram-negative bacteria, their distribution and the resistance genes
Incompatible plasmids play a crucial role in the horizontal transfer of antibiotic resistance in bacteria, particularly in Gram-negative bacteria, and have thus attracted considerable attention in the field of microbiological research. In the 1970s, these plasmids, housing an array of resistance gen...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-11-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2024.1472876/full |
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| author | Lei Fang Ruyan Chen Chenyu Li Jingjing Sun Ruishan Liu Yanhao Shen Xiaobing Guo |
| author_facet | Lei Fang Ruyan Chen Chenyu Li Jingjing Sun Ruishan Liu Yanhao Shen Xiaobing Guo |
| author_sort | Lei Fang |
| collection | DOAJ |
| description | Incompatible plasmids play a crucial role in the horizontal transfer of antibiotic resistance in bacteria, particularly in Gram-negative bacteria, and have thus attracted considerable attention in the field of microbiological research. In the 1970s, these plasmids, housing an array of resistance genes and genetic elements, were predominantly discovered. They exhibit a broad presence in diverse host bacteria, showcasing diversity in geographic distribution and the spectrum of antibiotic resistance genes. The complex genetic structure of plasmids further accelerates the accumulation of resistance genes in Gram-negative bacteria. This article offers a comprehensive review encompassing the discovery process, host distribution, geographic prevalence, carried resistance genes, and the genetic structure of different types incompatible plasmids, including IncA, IncC, IncF, IncL, IncM, IncH, and IncP. It serves as a valuable reference for enhancing our understanding of the role of these different types of plasmids in bacterial evolution and the dissemination of antibiotic resistance. |
| format | Article |
| id | doaj-art-bf8637e7156145faaff8b18d3edf8fff |
| institution | Kabale University |
| issn | 2235-2988 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj-art-bf8637e7156145faaff8b18d3edf8fff2024-11-26T06:26:30ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882024-11-011410.3389/fcimb.2024.14728761472876The association between the genetic structures of commonly incompatible plasmids in Gram-negative bacteria, their distribution and the resistance genesLei Fang0Ruyan Chen1Chenyu Li2Jingjing Sun3Ruishan Liu4Yanhao Shen5Xiaobing Guo6Department of Laboratory Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Laboratory Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Laboratory Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Laboratory Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaCollaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Laboratory Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Laboratory Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaIncompatible plasmids play a crucial role in the horizontal transfer of antibiotic resistance in bacteria, particularly in Gram-negative bacteria, and have thus attracted considerable attention in the field of microbiological research. In the 1970s, these plasmids, housing an array of resistance genes and genetic elements, were predominantly discovered. They exhibit a broad presence in diverse host bacteria, showcasing diversity in geographic distribution and the spectrum of antibiotic resistance genes. The complex genetic structure of plasmids further accelerates the accumulation of resistance genes in Gram-negative bacteria. This article offers a comprehensive review encompassing the discovery process, host distribution, geographic prevalence, carried resistance genes, and the genetic structure of different types incompatible plasmids, including IncA, IncC, IncF, IncL, IncM, IncH, and IncP. It serves as a valuable reference for enhancing our understanding of the role of these different types of plasmids in bacterial evolution and the dissemination of antibiotic resistance.https://www.frontiersin.org/articles/10.3389/fcimb.2024.1472876/fullgenetic structuresplasmidshorizontal gene transferresistance genesgenetic element |
| spellingShingle | Lei Fang Ruyan Chen Chenyu Li Jingjing Sun Ruishan Liu Yanhao Shen Xiaobing Guo The association between the genetic structures of commonly incompatible plasmids in Gram-negative bacteria, their distribution and the resistance genes Frontiers in Cellular and Infection Microbiology genetic structures plasmids horizontal gene transfer resistance genes genetic element |
| title | The association between the genetic structures of commonly incompatible plasmids in Gram-negative bacteria, their distribution and the resistance genes |
| title_full | The association between the genetic structures of commonly incompatible plasmids in Gram-negative bacteria, their distribution and the resistance genes |
| title_fullStr | The association between the genetic structures of commonly incompatible plasmids in Gram-negative bacteria, their distribution and the resistance genes |
| title_full_unstemmed | The association between the genetic structures of commonly incompatible plasmids in Gram-negative bacteria, their distribution and the resistance genes |
| title_short | The association between the genetic structures of commonly incompatible plasmids in Gram-negative bacteria, their distribution and the resistance genes |
| title_sort | association between the genetic structures of commonly incompatible plasmids in gram negative bacteria their distribution and the resistance genes |
| topic | genetic structures plasmids horizontal gene transfer resistance genes genetic element |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2024.1472876/full |
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