Obesity-induced fibrosis in osteoarthritis: Pathogenesis, consequences and novel therapeutic opportunities
Osteoarthritis (OA) is a significant global burden, affecting more than half a billion people across the world. It is characterized by degeneration and loss of articular cartilage, synovial inflammation, and subchondral bone sclerosis, leading to pain and functional impairment. After age, obesity is...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-12-01
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| Series: | Osteoarthritis and Cartilage Open |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2665913124000785 |
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| author | João Henriques Francis Berenbaum Ali Mobasheri |
| author_facet | João Henriques Francis Berenbaum Ali Mobasheri |
| author_sort | João Henriques |
| collection | DOAJ |
| description | Osteoarthritis (OA) is a significant global burden, affecting more than half a billion people across the world. It is characterized by degeneration and loss of articular cartilage, synovial inflammation, and subchondral bone sclerosis, leading to pain and functional impairment. After age, obesity is a major modifiable risk factor for OA, and it has recently been identified as a chronic disease by the World Health Organization (WHO). Obesity is associated with high morbidity and mortality, imposing a significant cost on individuals and society. Obesity increases the risk of knee OA through increased joint loading, altered body composition, and elevated pro-inflammatory adipokines in the systemic circulation. Moreover, obesity triggers fibrotic processes in different organs and tissues, including those involved in OA. Fibrosis in OA refers to the abnormal accumulation of fibrous tissue within and around the joints. It can be driven by increased adiposity, low-grade inflammation, oxidative stress, and metabolic alterations. However, the clinical outcomes of fibrosis in OA are unclear. This review focuses on the link between obesity and OA, explores the mechanism of obesity-driven fibrosis, and examines potential therapeutic opportunities for targeting fibrotic processes in OA. |
| format | Article |
| id | doaj-art-bf79a3e8ec4242c5972233a86a4a5d34 |
| institution | Kabale University |
| issn | 2665-9131 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Osteoarthritis and Cartilage Open |
| spelling | doaj-art-bf79a3e8ec4242c5972233a86a4a5d342024-11-27T05:03:04ZengElsevierOsteoarthritis and Cartilage Open2665-91312024-12-0164100511Obesity-induced fibrosis in osteoarthritis: Pathogenesis, consequences and novel therapeutic opportunitiesJoão Henriques0Francis Berenbaum1Ali Mobasheri2Research Unit of Health Sciences and Technology, Faculty of Medicine, University of Oulu, Oulu, FinlandSorbonne University, Paris, France; Department of Rheumatology, Saint-Antoine Hospital, Assistance Publique-Hopitaux de Paris, Paris, France; INSERM CRSA, Paris, FranceResearch Unit of Health Sciences and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland; State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania; Department of Joint Surgery, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China; World Health Organization Collaborating Center for Public Health Aspects of Musculoskeletal Health and Aging, Université de Liège, Liège, Belgium; Corresponding author.Osteoarthritis (OA) is a significant global burden, affecting more than half a billion people across the world. It is characterized by degeneration and loss of articular cartilage, synovial inflammation, and subchondral bone sclerosis, leading to pain and functional impairment. After age, obesity is a major modifiable risk factor for OA, and it has recently been identified as a chronic disease by the World Health Organization (WHO). Obesity is associated with high morbidity and mortality, imposing a significant cost on individuals and society. Obesity increases the risk of knee OA through increased joint loading, altered body composition, and elevated pro-inflammatory adipokines in the systemic circulation. Moreover, obesity triggers fibrotic processes in different organs and tissues, including those involved in OA. Fibrosis in OA refers to the abnormal accumulation of fibrous tissue within and around the joints. It can be driven by increased adiposity, low-grade inflammation, oxidative stress, and metabolic alterations. However, the clinical outcomes of fibrosis in OA are unclear. This review focuses on the link between obesity and OA, explores the mechanism of obesity-driven fibrosis, and examines potential therapeutic opportunities for targeting fibrotic processes in OA.http://www.sciencedirect.com/science/article/pii/S2665913124000785OsteoarthritisObesityFibrosisAdiposityImmunometabolic alterationsTherapeutic |
| spellingShingle | João Henriques Francis Berenbaum Ali Mobasheri Obesity-induced fibrosis in osteoarthritis: Pathogenesis, consequences and novel therapeutic opportunities Osteoarthritis and Cartilage Open Osteoarthritis Obesity Fibrosis Adiposity Immunometabolic alterations Therapeutic |
| title | Obesity-induced fibrosis in osteoarthritis: Pathogenesis, consequences and novel therapeutic opportunities |
| title_full | Obesity-induced fibrosis in osteoarthritis: Pathogenesis, consequences and novel therapeutic opportunities |
| title_fullStr | Obesity-induced fibrosis in osteoarthritis: Pathogenesis, consequences and novel therapeutic opportunities |
| title_full_unstemmed | Obesity-induced fibrosis in osteoarthritis: Pathogenesis, consequences and novel therapeutic opportunities |
| title_short | Obesity-induced fibrosis in osteoarthritis: Pathogenesis, consequences and novel therapeutic opportunities |
| title_sort | obesity induced fibrosis in osteoarthritis pathogenesis consequences and novel therapeutic opportunities |
| topic | Osteoarthritis Obesity Fibrosis Adiposity Immunometabolic alterations Therapeutic |
| url | http://www.sciencedirect.com/science/article/pii/S2665913124000785 |
| work_keys_str_mv | AT joaohenriques obesityinducedfibrosisinosteoarthritispathogenesisconsequencesandnoveltherapeuticopportunities AT francisberenbaum obesityinducedfibrosisinosteoarthritispathogenesisconsequencesandnoveltherapeuticopportunities AT alimobasheri obesityinducedfibrosisinosteoarthritispathogenesisconsequencesandnoveltherapeuticopportunities |