Invasive aspergillosis complicated in a patient with non-small cell lung cancer harboring RET fusion during treatment with RET-TKIs: a case report and literature review
Pralsetinib and selpercatinib have been approved as specific tyrosine kinase inhibitors (TKIs) for the treatment of patients with non-small cell lung cancer (NSCLC) harboring rearranged during transfection (RET) fusion and mutation. However, adverse events associated with pralsetinib and selpercatin...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2024-11-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1431908/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846163713972764672 |
|---|---|
| author | Kaidiriye Setiwalidi Yimeng Li Yuyan Ma Zhanpeng Hao Yujia Zhao Yuxin Zhang Xuan Liang Tao Tian Zhiping Ruan Yu Yao Xiao Fu |
| author_facet | Kaidiriye Setiwalidi Yimeng Li Yuyan Ma Zhanpeng Hao Yujia Zhao Yuxin Zhang Xuan Liang Tao Tian Zhiping Ruan Yu Yao Xiao Fu |
| author_sort | Kaidiriye Setiwalidi |
| collection | DOAJ |
| description | Pralsetinib and selpercatinib have been approved as specific tyrosine kinase inhibitors (TKIs) for the treatment of patients with non-small cell lung cancer (NSCLC) harboring rearranged during transfection (RET) fusion and mutation. However, adverse events associated with pralsetinib and selpercatinib are not fully understood, especially in the real world. In this case, invasive aspergillosis that appeared concurrent with RET-TKI targeted therapy is proposed to be an additional adverse drug reaction (ADR) that was not mentioned in previous reports. Here, we describe the process of clinical diagnosis and treatment of invasive aspergillosis and attempt to explore its possible pathogenesis in association with RET-TKI targeted therapy, with the aim of providing clinicians a more in-depth understanding of the ADR associated with RET-TKIs, as well as to prevent serious outcomes caused by reduction or discontinuation of antitumor therapy. |
| format | Article |
| id | doaj-art-bf72cd5c8d3d4d33930a7185f492a834 |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-bf72cd5c8d3d4d33930a7185f492a8342024-11-19T05:10:10ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2024-11-011410.3389/fonc.2024.14319081431908Invasive aspergillosis complicated in a patient with non-small cell lung cancer harboring RET fusion during treatment with RET-TKIs: a case report and literature reviewKaidiriye SetiwalidiYimeng LiYuyan MaZhanpeng HaoYujia ZhaoYuxin ZhangXuan LiangTao TianZhiping RuanYu YaoXiao FuPralsetinib and selpercatinib have been approved as specific tyrosine kinase inhibitors (TKIs) for the treatment of patients with non-small cell lung cancer (NSCLC) harboring rearranged during transfection (RET) fusion and mutation. However, adverse events associated with pralsetinib and selpercatinib are not fully understood, especially in the real world. In this case, invasive aspergillosis that appeared concurrent with RET-TKI targeted therapy is proposed to be an additional adverse drug reaction (ADR) that was not mentioned in previous reports. Here, we describe the process of clinical diagnosis and treatment of invasive aspergillosis and attempt to explore its possible pathogenesis in association with RET-TKI targeted therapy, with the aim of providing clinicians a more in-depth understanding of the ADR associated with RET-TKIs, as well as to prevent serious outcomes caused by reduction or discontinuation of antitumor therapy.https://www.frontiersin.org/articles/10.3389/fonc.2024.1431908/fullNSCLCRETpralsetinibselpercatinibinvasive aspergillosis |
| spellingShingle | Kaidiriye Setiwalidi Yimeng Li Yuyan Ma Zhanpeng Hao Yujia Zhao Yuxin Zhang Xuan Liang Tao Tian Zhiping Ruan Yu Yao Xiao Fu Invasive aspergillosis complicated in a patient with non-small cell lung cancer harboring RET fusion during treatment with RET-TKIs: a case report and literature review Frontiers in Oncology NSCLC RET pralsetinib selpercatinib invasive aspergillosis |
| title | Invasive aspergillosis complicated in a patient with non-small cell lung cancer harboring RET fusion during treatment with RET-TKIs: a case report and literature review |
| title_full | Invasive aspergillosis complicated in a patient with non-small cell lung cancer harboring RET fusion during treatment with RET-TKIs: a case report and literature review |
| title_fullStr | Invasive aspergillosis complicated in a patient with non-small cell lung cancer harboring RET fusion during treatment with RET-TKIs: a case report and literature review |
| title_full_unstemmed | Invasive aspergillosis complicated in a patient with non-small cell lung cancer harboring RET fusion during treatment with RET-TKIs: a case report and literature review |
| title_short | Invasive aspergillosis complicated in a patient with non-small cell lung cancer harboring RET fusion during treatment with RET-TKIs: a case report and literature review |
| title_sort | invasive aspergillosis complicated in a patient with non small cell lung cancer harboring ret fusion during treatment with ret tkis a case report and literature review |
| topic | NSCLC RET pralsetinib selpercatinib invasive aspergillosis |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2024.1431908/full |
| work_keys_str_mv | AT kaidiriyesetiwalidi invasiveaspergillosiscomplicatedinapatientwithnonsmallcelllungcancerharboringretfusionduringtreatmentwithrettkisacasereportandliteraturereview AT yimengli invasiveaspergillosiscomplicatedinapatientwithnonsmallcelllungcancerharboringretfusionduringtreatmentwithrettkisacasereportandliteraturereview AT yuyanma invasiveaspergillosiscomplicatedinapatientwithnonsmallcelllungcancerharboringretfusionduringtreatmentwithrettkisacasereportandliteraturereview AT zhanpenghao invasiveaspergillosiscomplicatedinapatientwithnonsmallcelllungcancerharboringretfusionduringtreatmentwithrettkisacasereportandliteraturereview AT yujiazhao invasiveaspergillosiscomplicatedinapatientwithnonsmallcelllungcancerharboringretfusionduringtreatmentwithrettkisacasereportandliteraturereview AT yuxinzhang invasiveaspergillosiscomplicatedinapatientwithnonsmallcelllungcancerharboringretfusionduringtreatmentwithrettkisacasereportandliteraturereview AT xuanliang invasiveaspergillosiscomplicatedinapatientwithnonsmallcelllungcancerharboringretfusionduringtreatmentwithrettkisacasereportandliteraturereview AT taotian invasiveaspergillosiscomplicatedinapatientwithnonsmallcelllungcancerharboringretfusionduringtreatmentwithrettkisacasereportandliteraturereview AT zhipingruan invasiveaspergillosiscomplicatedinapatientwithnonsmallcelllungcancerharboringretfusionduringtreatmentwithrettkisacasereportandliteraturereview AT yuyao invasiveaspergillosiscomplicatedinapatientwithnonsmallcelllungcancerharboringretfusionduringtreatmentwithrettkisacasereportandliteraturereview AT xiaofu invasiveaspergillosiscomplicatedinapatientwithnonsmallcelllungcancerharboringretfusionduringtreatmentwithrettkisacasereportandliteraturereview |