P-glycoprotein-independent cytotoxic effects of 5-aminopyrazole in L1210 leukemia cells
We previously investigated the cytotoxic effects of 5-aminopyrazoles (5-APs) on leukemia cells both negative and positive for P-glycoprotein (P-gp) expression, a common contributor to multidrug resistance. Five derivatives (A1-A5), each containing perfluorinated methylbenzene at the N3 nitrogen of t...
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Main Authors: | Lucia Sofrankova, Jana Spaldova, Pavol Stefik, Branislav Pavilek, Dusan Bortnak, Lucia Pavlikova, Ivana Zidekova, Daniel Vegh, Viktor Milata, Albert Breier, Zdena Sulova |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2025-04-01
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Series: | European Journal of Medicinal Chemistry Reports |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2772417425000020 |
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