P-glycoprotein-independent cytotoxic effects of 5-aminopyrazole in L1210 leukemia cells

P-glycoprotein-independent cytotoxic effects of 5-aminopyrazole in L1210 leukemia cells

We previously investigated the cytotoxic effects of 5-aminopyrazoles (5-APs) on leukemia cells both negative and positive for P-glycoprotein (P-gp) expression, a common contributor to multidrug resistance. Five derivatives (A1-A5), each containing perfluorinated methylbenzene at the N3 nitrogen of t...

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Bibliographic Details
Main Authors: Lucia Sofrankova, Jana Spaldova, Pavol Stefik, Branislav Pavilek, Dusan Bortnak, Lucia Pavlikova, Ivana Zidekova, Daniel Vegh, Viktor Milata, Albert Breier, Zdena Sulova
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:European Journal of Medicinal Chemistry Reports
Subjects:
5-Aminopyrazoles
Cancer
Cell death
P-glycoprotein
Online Access:http://www.sciencedirect.com/science/article/pii/S2772417425000020
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