The effects of quercetin on antioxidant system and some blood parameters in rats exposed to acute cadmium toxicity
<b>Aim: </b>The aim of this study was to determine the effects of quercetin on antioxidant system and some blood parameters in rats exposed to acute cadmium toxicity.<p> <b>Materials and Methods:</b> Adult male Wistar-Albino rats (n = 30) were used and divided into four...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Selcuk University Press
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| Series: | Eurasian Journal of Veterinary Sciences |
| Subjects: | |
| Online Access: | http://eurasianjvetsci.org/pdf.php3?id=1244 |
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| Summary: | <b>Aim: </b>The aim of this study was to determine the effects of quercetin
on antioxidant system and some blood parameters in
rats exposed to acute cadmium toxicity.<p>
<b>Materials and Methods:</b> Adult male Wistar-Albino rats (n
= 30) were used and divided into four groups as Control (C, n
= 6), Cadmium (Cd, n = 8), Quercetin (Q, n = 8) and Cadmium
+ Quercetin (Cd + Q, n = 8). Cadmium chloride (CdCl2, 4 mg/
kg daily, s.c) were administrated to Cd and Cd+Q groups, and
Quercetin (Q, 50 mg/kg daily, i.p) were given to Q and Cd + Q
groups for 3 days, respectively. Control group was not recieved
any treatment. Blood samples were collected from all animals
at fourth day after treatments.<p>
<b>Results:</b> The levels of serum SOD, MDA, GSH, catalase, and
plasma ALT, AST, GGT, total protein, albumin were detected.
Although, serum MDA levels were found higher (P< 0.05) in
Cd than the other groups, it was similiar in Q and C groups.
ALT, AST and GGT enzyme levels were observed higher in Cd
than C and Q groups (P< 0.05).<p>
<b>Conclusion:</b> Negative effects of acute cadmium toxicity on
antioxidan system and some hematological parameters were
ameliorated with quercetin treatment in rats. |
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| ISSN: | 1309-6958 2146-1953 |