Current Advances in Molecular Imaging: Noninvasive in Vivo Bioluminescent and Fluorescent Optical Imaging in Cancer Research
Recently, there has been tremendous interest in developing techniques such as MRI, micro-CT, micro-PET, and SPECT to image function and processes in small animals. These technologies offer deep tissue penetration and high spatial resolution, but compared with noninvasive small animal optical imaging...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2003-10-01
|
| Series: | Molecular Imaging |
| Online Access: | https://doi.org/10.1162/15353500200303142 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841564581364760576 |
|---|---|
| author | Garry Choy Peter Choyke Steven K Libutti |
| author_facet | Garry Choy Peter Choyke Steven K Libutti |
| author_sort | Garry Choy |
| collection | DOAJ |
| description | Recently, there has been tremendous interest in developing techniques such as MRI, micro-CT, micro-PET, and SPECT to image function and processes in small animals. These technologies offer deep tissue penetration and high spatial resolution, but compared with noninvasive small animal optical imaging, these techniques are very costly and time consuming to implement. Optical imaging is cost-effective, rapid, easy to use, and can be readily applied to studying disease processes and biology in vivo. In vivo optical imaging is the result of a coalescence of technologies from chemistry, physics, and biology. The development of highly sensitive light detection systems has allowed biologists to use imaging in studying physiological processes. Over the last few decades, biochemists have also worked to isolate and further develop optical reporters such as GFP, luciferase, and cyanine dyes. This article reviews the common types of fluorescent and bioluminescent optical imaging, the typical system platforms and configurations, and the applications in the investigation of cancer biology. |
| format | Article |
| id | doaj-art-bf62d19d494443f1b06f54bd840fd648 |
| institution | Kabale University |
| issn | 1536-0121 |
| language | English |
| publishDate | 2003-10-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Molecular Imaging |
| spelling | doaj-art-bf62d19d494443f1b06f54bd840fd6482025-01-02T22:37:25ZengSAGE PublishingMolecular Imaging1536-01212003-10-01210.1162/1535350020030314210.1162_15353500200303142Current Advances in Molecular Imaging: Noninvasive in Vivo Bioluminescent and Fluorescent Optical Imaging in Cancer ResearchGarry Choy0Peter Choyke1Steven K Libutti2Howard Hughes Medical InstituteWarren G. Magnuson Clinical CenterNational Cancer InstituteRecently, there has been tremendous interest in developing techniques such as MRI, micro-CT, micro-PET, and SPECT to image function and processes in small animals. These technologies offer deep tissue penetration and high spatial resolution, but compared with noninvasive small animal optical imaging, these techniques are very costly and time consuming to implement. Optical imaging is cost-effective, rapid, easy to use, and can be readily applied to studying disease processes and biology in vivo. In vivo optical imaging is the result of a coalescence of technologies from chemistry, physics, and biology. The development of highly sensitive light detection systems has allowed biologists to use imaging in studying physiological processes. Over the last few decades, biochemists have also worked to isolate and further develop optical reporters such as GFP, luciferase, and cyanine dyes. This article reviews the common types of fluorescent and bioluminescent optical imaging, the typical system platforms and configurations, and the applications in the investigation of cancer biology.https://doi.org/10.1162/15353500200303142 |
| spellingShingle | Garry Choy Peter Choyke Steven K Libutti Current Advances in Molecular Imaging: Noninvasive in Vivo Bioluminescent and Fluorescent Optical Imaging in Cancer Research Molecular Imaging |
| title | Current Advances in Molecular Imaging: Noninvasive in Vivo Bioluminescent and Fluorescent Optical Imaging in Cancer Research |
| title_full | Current Advances in Molecular Imaging: Noninvasive in Vivo Bioluminescent and Fluorescent Optical Imaging in Cancer Research |
| title_fullStr | Current Advances in Molecular Imaging: Noninvasive in Vivo Bioluminescent and Fluorescent Optical Imaging in Cancer Research |
| title_full_unstemmed | Current Advances in Molecular Imaging: Noninvasive in Vivo Bioluminescent and Fluorescent Optical Imaging in Cancer Research |
| title_short | Current Advances in Molecular Imaging: Noninvasive in Vivo Bioluminescent and Fluorescent Optical Imaging in Cancer Research |
| title_sort | current advances in molecular imaging noninvasive in vivo bioluminescent and fluorescent optical imaging in cancer research |
| url | https://doi.org/10.1162/15353500200303142 |
| work_keys_str_mv | AT garrychoy currentadvancesinmolecularimagingnoninvasiveinvivobioluminescentandfluorescentopticalimagingincancerresearch AT peterchoyke currentadvancesinmolecularimagingnoninvasiveinvivobioluminescentandfluorescentopticalimagingincancerresearch AT stevenklibutti currentadvancesinmolecularimagingnoninvasiveinvivobioluminescentandfluorescentopticalimagingincancerresearch |