Association of immune-inflammation indexes with incidence and prognosis of diabetic nephropathy: a systematic review and meta-analysis
IntroductionThe significance of immune-inflammation indexes in diabetic nephropathy (DN) was assessed in this meta-analysis to offer guidance for clinical diagnosis and treatment for DN.MethodsWe performed a meta-analysis on the association between immune-inflammation indexes and the incidence and p...
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Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2025.1532682/full |
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| author | Yijue Wang Yijue Wang Yijue Wang Yan Liu Wenling Gu Boyu Cai Min Lei Min Lei Yingyu Luo Yingyu Luo Nannan Zhang Nannan Zhang |
| author_facet | Yijue Wang Yijue Wang Yijue Wang Yan Liu Wenling Gu Boyu Cai Min Lei Min Lei Yingyu Luo Yingyu Luo Nannan Zhang Nannan Zhang |
| author_sort | Yijue Wang |
| collection | DOAJ |
| description | IntroductionThe significance of immune-inflammation indexes in diabetic nephropathy (DN) was assessed in this meta-analysis to offer guidance for clinical diagnosis and treatment for DN.MethodsWe performed a meta-analysis on the association between immune-inflammation indexes and the incidence and prognosis of DN, specifically focusing on the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), systemic immune-inflammation index (SII), and systemic inflammation response index (SIRI). We thoroughly searched PubMed, Web of Science, Embase, and Cochrane from inception to September 2024. The statistical analysis was performed using R 4.2.3 software.Results56 studies were ultimately included, comprising 50 that examined the association between DN incidence and immune-inflammation indexes and 8 that examined the association between DN prognosis and immune-inflammation indexes. The levels of NLR, MLR, PLR, and SII were significantly higher in DN patients than in non-DN ones. Besides, high NLR, MLR, SII, and SIRI were associated with elevated incidence of DN. Moreover, the high NLR group was more prone to a poor prognosis than the low NLR group (OR: 1.372, 95% CI: 1.160-1.624).ConclusionsImmune-inflammation indexes can, to a certain extent, serve as a biomarker to predict the occurrence of DN. In addition, high NLR has a potential association with the occurrence of poor prognosis in DN. |
| format | Article |
| id | doaj-art-bf4a486f4d1948c0a37f396abbf727b9 |
| institution | Kabale University |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Endocrinology |
| spelling | doaj-art-bf4a486f4d1948c0a37f396abbf727b92025-08-20T03:46:45ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-08-011610.3389/fendo.2025.15326821532682Association of immune-inflammation indexes with incidence and prognosis of diabetic nephropathy: a systematic review and meta-analysisYijue Wang0Yijue Wang1Yijue Wang2Yan Liu3Wenling Gu4Boyu Cai5Min Lei6Min Lei7Yingyu Luo8Yingyu Luo9Nannan Zhang10Nannan Zhang11National Center for Birth Defect Monitoring, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, ChinaWest China School of Stomatology, Sichuan University, Chengdu, Sichuan, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Sichuan University, Chengdu, Sichuan, ChinaScaled Manufacturing Center of Biological Products, Management Office of National Facility for Translational Medicine, West China Hospital of Sichuan University, Chengdu, ChinaCollege of Life Sciences, Sichuan University, Chengdu, Sichuan, ChinaCollege of Life Sciences, Sichuan University, Chengdu, Sichuan, ChinaNational Center for Birth Defect Monitoring, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Sichuan University, Chengdu, Sichuan, ChinaNational Center for Birth Defect Monitoring, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Sichuan University, Chengdu, Sichuan, ChinaNational Center for Birth Defect Monitoring, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Sichuan University, Chengdu, Sichuan, ChinaIntroductionThe significance of immune-inflammation indexes in diabetic nephropathy (DN) was assessed in this meta-analysis to offer guidance for clinical diagnosis and treatment for DN.MethodsWe performed a meta-analysis on the association between immune-inflammation indexes and the incidence and prognosis of DN, specifically focusing on the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), systemic immune-inflammation index (SII), and systemic inflammation response index (SIRI). We thoroughly searched PubMed, Web of Science, Embase, and Cochrane from inception to September 2024. The statistical analysis was performed using R 4.2.3 software.Results56 studies were ultimately included, comprising 50 that examined the association between DN incidence and immune-inflammation indexes and 8 that examined the association between DN prognosis and immune-inflammation indexes. The levels of NLR, MLR, PLR, and SII were significantly higher in DN patients than in non-DN ones. Besides, high NLR, MLR, SII, and SIRI were associated with elevated incidence of DN. Moreover, the high NLR group was more prone to a poor prognosis than the low NLR group (OR: 1.372, 95% CI: 1.160-1.624).ConclusionsImmune-inflammation indexes can, to a certain extent, serve as a biomarker to predict the occurrence of DN. In addition, high NLR has a potential association with the occurrence of poor prognosis in DN.https://www.frontiersin.org/articles/10.3389/fendo.2025.1532682/fulldiabetic nephropathyimmune-inflammation indexbiomarkersdiagnostic techniquesprognosismeta-analysis |
| spellingShingle | Yijue Wang Yijue Wang Yijue Wang Yan Liu Wenling Gu Boyu Cai Min Lei Min Lei Yingyu Luo Yingyu Luo Nannan Zhang Nannan Zhang Association of immune-inflammation indexes with incidence and prognosis of diabetic nephropathy: a systematic review and meta-analysis Frontiers in Endocrinology diabetic nephropathy immune-inflammation index biomarkers diagnostic techniques prognosis meta-analysis |
| title | Association of immune-inflammation indexes with incidence and prognosis of diabetic nephropathy: a systematic review and meta-analysis |
| title_full | Association of immune-inflammation indexes with incidence and prognosis of diabetic nephropathy: a systematic review and meta-analysis |
| title_fullStr | Association of immune-inflammation indexes with incidence and prognosis of diabetic nephropathy: a systematic review and meta-analysis |
| title_full_unstemmed | Association of immune-inflammation indexes with incidence and prognosis of diabetic nephropathy: a systematic review and meta-analysis |
| title_short | Association of immune-inflammation indexes with incidence and prognosis of diabetic nephropathy: a systematic review and meta-analysis |
| title_sort | association of immune inflammation indexes with incidence and prognosis of diabetic nephropathy a systematic review and meta analysis |
| topic | diabetic nephropathy immune-inflammation index biomarkers diagnostic techniques prognosis meta-analysis |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2025.1532682/full |
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