Transcatheter Aortic Valve Durability: Focus on Structural Valve Deterioration
Transcatheter aortic valve replacement has emerged as a valuable alternative to surgical aortic valve replacement in patients with severe aortic stenosis. Given the expansion of transcatheter aortic valve replacement to lower‐risk and younger populations with longer life expectancy, the durability o...
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Wiley
2025-07-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
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| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.125.041505 |
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| author | Antonin Trimaille Adrien Carmona Sandy Hmadeh Dinh Phi Truong Benjamin Marchandot Shinnosuke Kikuchi Kensuke Matsushita Patrick Ohlmann Valérie Schini‐Kerth Josep Rodés‐Cabau Philippe Pibarot Olivier Morel |
| author_facet | Antonin Trimaille Adrien Carmona Sandy Hmadeh Dinh Phi Truong Benjamin Marchandot Shinnosuke Kikuchi Kensuke Matsushita Patrick Ohlmann Valérie Schini‐Kerth Josep Rodés‐Cabau Philippe Pibarot Olivier Morel |
| author_sort | Antonin Trimaille |
| collection | DOAJ |
| description | Transcatheter aortic valve replacement has emerged as a valuable alternative to surgical aortic valve replacement in patients with severe aortic stenosis. Given the expansion of transcatheter aortic valve replacement to lower‐risk and younger populations with longer life expectancy, the durability of transcatheter heart valves (THVs) has become an important issue that may impact cardiovascular outcomes. THVs share similarities with surgical valves but have unique features, including a trend to larger effective orifice area and less prosthesis–patient mismatch, interactions with the native valve, and crimping process, that may all potentially influence a THV's life span. Multiple mechanisms may lead to bioprosthetic valve dysfunction, including structural valve deterioration, thrombosis, endocarditis, and nonstructural valve deterioration. With an incidence of up to 12.3% 5 years after transcatheter aortic valve replacement, structural valve deterioration represents the ultimate consequence of fibrotic remodeling and calcification within the bioprosthesis, driven by thrombotic and inflammatory processes involving the native aortic valve and influenced by patient and procedural factors. Understanding these mechanisms is crucial for improving THV durability. |
| format | Article |
| id | doaj-art-bf47dfc70b4d42148d6d5852d27e2d46 |
| institution | Kabale University |
| issn | 2047-9980 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj-art-bf47dfc70b4d42148d6d5852d27e2d462025-08-20T03:58:49ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802025-07-01141310.1161/JAHA.125.041505Transcatheter Aortic Valve Durability: Focus on Structural Valve DeteriorationAntonin Trimaille0Adrien Carmona1Sandy Hmadeh2Dinh Phi Truong3Benjamin Marchandot4Shinnosuke Kikuchi5Kensuke Matsushita6Patrick Ohlmann7Valérie Schini‐Kerth8Josep Rodés‐Cabau9Philippe Pibarot10Olivier Morel11Department of Cardiovascular Medicine, Nouvel Hôpital Civil Strasbourg University Hospital Strasbourg FranceDepartment of Cardiovascular Medicine, Nouvel Hôpital Civil Strasbourg University Hospital Strasbourg FranceUR 3074, Translational Cardiovascular Medicine, CRBS University of Strasbourg Strasbourg FranceHanoï Medical University Hanoï VietnamDepartment of Cardiovascular Medicine, Nouvel Hôpital Civil Strasbourg University Hospital Strasbourg FranceDepartment of Cardiovascular Medicine, Nouvel Hôpital Civil Strasbourg University Hospital Strasbourg FranceDepartment of Cardiovascular Medicine, Nouvel Hôpital Civil Strasbourg University Hospital Strasbourg FranceDepartment of Cardiovascular Medicine, Nouvel Hôpital Civil Strasbourg University Hospital Strasbourg FranceUR 3074, Translational Cardiovascular Medicine, CRBS University of Strasbourg Strasbourg FranceQuébec Heart and Lung Institute Laval University Québec City QC CanadaQuébec Heart and Lung Institute Laval University Québec City QC CanadaDepartment of Cardiovascular Medicine, Nouvel Hôpital Civil Strasbourg University Hospital Strasbourg FranceTranscatheter aortic valve replacement has emerged as a valuable alternative to surgical aortic valve replacement in patients with severe aortic stenosis. Given the expansion of transcatheter aortic valve replacement to lower‐risk and younger populations with longer life expectancy, the durability of transcatheter heart valves (THVs) has become an important issue that may impact cardiovascular outcomes. THVs share similarities with surgical valves but have unique features, including a trend to larger effective orifice area and less prosthesis–patient mismatch, interactions with the native valve, and crimping process, that may all potentially influence a THV's life span. Multiple mechanisms may lead to bioprosthetic valve dysfunction, including structural valve deterioration, thrombosis, endocarditis, and nonstructural valve deterioration. With an incidence of up to 12.3% 5 years after transcatheter aortic valve replacement, structural valve deterioration represents the ultimate consequence of fibrotic remodeling and calcification within the bioprosthesis, driven by thrombotic and inflammatory processes involving the native aortic valve and influenced by patient and procedural factors. Understanding these mechanisms is crucial for improving THV durability.https://www.ahajournals.org/doi/10.1161/JAHA.125.041505bioprosthetic valve failuredurabilitystructural valve deteriorationtranscatheter aortic valve replacementtranscatheter heart valve |
| spellingShingle | Antonin Trimaille Adrien Carmona Sandy Hmadeh Dinh Phi Truong Benjamin Marchandot Shinnosuke Kikuchi Kensuke Matsushita Patrick Ohlmann Valérie Schini‐Kerth Josep Rodés‐Cabau Philippe Pibarot Olivier Morel Transcatheter Aortic Valve Durability: Focus on Structural Valve Deterioration Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease bioprosthetic valve failure durability structural valve deterioration transcatheter aortic valve replacement transcatheter heart valve |
| title | Transcatheter Aortic Valve Durability: Focus on Structural Valve Deterioration |
| title_full | Transcatheter Aortic Valve Durability: Focus on Structural Valve Deterioration |
| title_fullStr | Transcatheter Aortic Valve Durability: Focus on Structural Valve Deterioration |
| title_full_unstemmed | Transcatheter Aortic Valve Durability: Focus on Structural Valve Deterioration |
| title_short | Transcatheter Aortic Valve Durability: Focus on Structural Valve Deterioration |
| title_sort | transcatheter aortic valve durability focus on structural valve deterioration |
| topic | bioprosthetic valve failure durability structural valve deterioration transcatheter aortic valve replacement transcatheter heart valve |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.125.041505 |
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