The impact of age on mortality in the intensive care unit: a retrospective cohort study in Malaysia
Background Age is a significant consideration for intensive care unit (ICU) admission. However, the reported associations between increasing age and mortality vary across studies, and data in the local context of Malaysia are lacking. The objective of the present study was to determine the impact of...
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Korean Society of Critical Care Medicine
2024-08-01
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| Series: | Acute and Critical Care |
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| Online Access: | http://www.accjournal.org/upload/pdf/acc-2024-00640.pdf |
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| author | Abdul Jabbar Ismail W Mohd Nazaruddin W Hassan Mohd Basri Mat Nor Wan Fadzlina Wan Muhd Shukeri1 |
| author_facet | Abdul Jabbar Ismail W Mohd Nazaruddin W Hassan Mohd Basri Mat Nor Wan Fadzlina Wan Muhd Shukeri1 |
| author_sort | Abdul Jabbar Ismail |
| collection | DOAJ |
| description | Background Age is a significant consideration for intensive care unit (ICU) admission. However, the reported associations between increasing age and mortality vary across studies, and data in the local context of Malaysia are lacking. The objective of the present study was to determine the impact of increasing age on ICU mortality. Methods A retrospective cohort study of ICU patients was conducted between January 2020 and November 2023 at a university hospital in Malaysia. Patients were classified into two categories according to age (years) and into four groups according to National Library of Medicine Medical Subject Headings (MeSH): young adult (19–24), adult (25–44), middle age (45–64), and elderly (≥65). The Cochran-Armitage test for trend and Cox proportional hazards regression analyses were performed to evaluate the impact of increasing age on ICU mortality. Results A total of 1,661 patients was analyzed. The Cochran-Armitage test showed a significant positive association between ICU mortality rate and age group (Z= −4.86, P<0.01) or MeSH category (Z=−5.36, P<0.01). After adjusting for other confounders, the strongest predictor for ICU mortality in the Cox proportional hazards regression analyses was age, with the elderly age group having the highest adjusted hazard ratio of 4.777 (95% CI, 1.128–20.231; P=0.03). Conclusions Age had a significant impact on ICU mortality in our cohort of critically ill patients. |
| format | Article |
| id | doaj-art-bf1dc4c8306d449e912b36fe0ac8445a |
| institution | Kabale University |
| issn | 2586-6052 2586-6060 |
| language | English |
| publishDate | 2024-08-01 |
| publisher | Korean Society of Critical Care Medicine |
| record_format | Article |
| series | Acute and Critical Care |
| spelling | doaj-art-bf1dc4c8306d449e912b36fe0ac8445a2024-11-18T23:51:10ZengKorean Society of Critical Care MedicineAcute and Critical Care2586-60522586-60602024-08-0139339039910.4266/acc.2024.006401542The impact of age on mortality in the intensive care unit: a retrospective cohort study in MalaysiaAbdul Jabbar Ismail0W Mohd Nazaruddin W Hassan1Mohd Basri Mat Nor2Wan Fadzlina Wan Muhd Shukeri13 School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Malaysia School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Malaysia Kulliyyah of Medicine, International Islamic University, Kuantan, Malaysia School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, MalaysiaBackground Age is a significant consideration for intensive care unit (ICU) admission. However, the reported associations between increasing age and mortality vary across studies, and data in the local context of Malaysia are lacking. The objective of the present study was to determine the impact of increasing age on ICU mortality. Methods A retrospective cohort study of ICU patients was conducted between January 2020 and November 2023 at a university hospital in Malaysia. Patients were classified into two categories according to age (years) and into four groups according to National Library of Medicine Medical Subject Headings (MeSH): young adult (19–24), adult (25–44), middle age (45–64), and elderly (≥65). The Cochran-Armitage test for trend and Cox proportional hazards regression analyses were performed to evaluate the impact of increasing age on ICU mortality. Results A total of 1,661 patients was analyzed. The Cochran-Armitage test showed a significant positive association between ICU mortality rate and age group (Z= −4.86, P<0.01) or MeSH category (Z=−5.36, P<0.01). After adjusting for other confounders, the strongest predictor for ICU mortality in the Cox proportional hazards regression analyses was age, with the elderly age group having the highest adjusted hazard ratio of 4.777 (95% CI, 1.128–20.231; P=0.03). Conclusions Age had a significant impact on ICU mortality in our cohort of critically ill patients.http://www.accjournal.org/upload/pdf/acc-2024-00640.pdfage groupsagedintensive care unitsmortalityprognosis |
| spellingShingle | Abdul Jabbar Ismail W Mohd Nazaruddin W Hassan Mohd Basri Mat Nor Wan Fadzlina Wan Muhd Shukeri1 The impact of age on mortality in the intensive care unit: a retrospective cohort study in Malaysia Acute and Critical Care age groups aged intensive care units mortality prognosis |
| title | The impact of age on mortality in the intensive care unit: a retrospective cohort study in Malaysia |
| title_full | The impact of age on mortality in the intensive care unit: a retrospective cohort study in Malaysia |
| title_fullStr | The impact of age on mortality in the intensive care unit: a retrospective cohort study in Malaysia |
| title_full_unstemmed | The impact of age on mortality in the intensive care unit: a retrospective cohort study in Malaysia |
| title_short | The impact of age on mortality in the intensive care unit: a retrospective cohort study in Malaysia |
| title_sort | impact of age on mortality in the intensive care unit a retrospective cohort study in malaysia |
| topic | age groups aged intensive care units mortality prognosis |
| url | http://www.accjournal.org/upload/pdf/acc-2024-00640.pdf |
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