Characterization of a STAT-1 Knockout Mouse Model for Machupo Virus Infection and Pathogenesis

Characterization of a STAT-1 Knockout Mouse Model for Machupo Virus Infection and Pathogenesis

Machupo virus (MACV), a member of the <i>Arenaviridae</i> family and causative agent of Bolivian hemorrhagic fever, results in lethality rates of 25–35% in humans. Mice lacking the signal transducer and activator of transcription 1 (STAT-1<sup>−/−</sup>) have previously been...

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Bibliographic Details
Main Authors: Stephanie R. Monticelli, Ana I. Kuehne, Russell R. Bakken, Susan R. Coyne, Kenise D. Lewis, Jo Lynne W. Raymond, Xiankun Zeng, Joshua B. Richardson, Zebulon Lapoint, Jennifer L. Williams, Christopher P. Stefan, Jeffrey R. Kugelman, Jeffrey W. Koehler, Andrew S. Herbert
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Viruses
Subjects:
arenavirus
STAT1
Machupo virus
arenavirus mouse models
Online Access:https://www.mdpi.com/1999-4915/17/7/996
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