Predictive control of pore architecture in ice-templated scaffolds via heat flux density modulation
Replicating the intricate architecture of native tissues remains a significant challenge in tissue engineering. Ice-templated biomimetic scaffolds possess controlled porosity that conveniently resembles the native parenchyma of many tissues. In this study, we investigate the relationship between the...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-12-01
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| Series: | Materials Today Advances |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590049824000808 |
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| author | Gengyao Wei Ruth E. Cameron Serena M. Best |
| author_facet | Gengyao Wei Ruth E. Cameron Serena M. Best |
| author_sort | Gengyao Wei |
| collection | DOAJ |
| description | Replicating the intricate architecture of native tissues remains a significant challenge in tissue engineering. Ice-templated biomimetic scaffolds possess controlled porosity that conveniently resembles the native parenchyma of many tissues. In this study, we investigate the relationship between the porous architecture of lyophilised collagen scaffolds and key processing parameters during production. We establish a predictive model that correlates specific lyophilisation conditions with the resulting pore sizes. Systematic variations in the freeze-drying conditions resulted in scaffolds with average pore sizes ranging from 46 μm to 251 μm, effectively matching the length scale of extracellular matrix features found in native tissues. We introduce the concept of heat flux density (HFD) at equilibrium as a metric for quantifying latent heat extraction efficiency during the freezing process. Our findings reveal a power law relationship between HFD at equilibrium and pore size, with an exponent of −0.44. This approach provides a non-destructive and non-intrusive method for precisely controlling pore architecture, advancing the potential for creating scaffolds that closely emulate the complex structures of native tissues. |
| format | Article |
| id | doaj-art-bf13a2c4d7df4c1daf58d49cc35b7c32 |
| institution | Kabale University |
| issn | 2590-0498 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Advances |
| spelling | doaj-art-bf13a2c4d7df4c1daf58d49cc35b7c322024-12-14T06:32:33ZengElsevierMaterials Today Advances2590-04982024-12-0124100543Predictive control of pore architecture in ice-templated scaffolds via heat flux density modulationGengyao Wei0Ruth E. Cameron1Serena M. Best2Corresponding author.; Department of Materials Science and Metallurgy, University of Cambridge, 27 Charles Babbage Road, Cambridge, CB3 0FT, UKDepartment of Materials Science and Metallurgy, University of Cambridge, 27 Charles Babbage Road, Cambridge, CB3 0FT, UKDepartment of Materials Science and Metallurgy, University of Cambridge, 27 Charles Babbage Road, Cambridge, CB3 0FT, UKReplicating the intricate architecture of native tissues remains a significant challenge in tissue engineering. Ice-templated biomimetic scaffolds possess controlled porosity that conveniently resembles the native parenchyma of many tissues. In this study, we investigate the relationship between the porous architecture of lyophilised collagen scaffolds and key processing parameters during production. We establish a predictive model that correlates specific lyophilisation conditions with the resulting pore sizes. Systematic variations in the freeze-drying conditions resulted in scaffolds with average pore sizes ranging from 46 μm to 251 μm, effectively matching the length scale of extracellular matrix features found in native tissues. We introduce the concept of heat flux density (HFD) at equilibrium as a metric for quantifying latent heat extraction efficiency during the freezing process. Our findings reveal a power law relationship between HFD at equilibrium and pore size, with an exponent of −0.44. This approach provides a non-destructive and non-intrusive method for precisely controlling pore architecture, advancing the potential for creating scaffolds that closely emulate the complex structures of native tissues.http://www.sciencedirect.com/science/article/pii/S2590049824000808Freeze-dryingIce-templatingLyophilisationCollagen scaffoldsHeat flux density |
| spellingShingle | Gengyao Wei Ruth E. Cameron Serena M. Best Predictive control of pore architecture in ice-templated scaffolds via heat flux density modulation Materials Today Advances Freeze-drying Ice-templating Lyophilisation Collagen scaffolds Heat flux density |
| title | Predictive control of pore architecture in ice-templated scaffolds via heat flux density modulation |
| title_full | Predictive control of pore architecture in ice-templated scaffolds via heat flux density modulation |
| title_fullStr | Predictive control of pore architecture in ice-templated scaffolds via heat flux density modulation |
| title_full_unstemmed | Predictive control of pore architecture in ice-templated scaffolds via heat flux density modulation |
| title_short | Predictive control of pore architecture in ice-templated scaffolds via heat flux density modulation |
| title_sort | predictive control of pore architecture in ice templated scaffolds via heat flux density modulation |
| topic | Freeze-drying Ice-templating Lyophilisation Collagen scaffolds Heat flux density |
| url | http://www.sciencedirect.com/science/article/pii/S2590049824000808 |
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