Molecular patterns of the NO-sGC-cGMP pathway in progressive and regressive liver fibrosis models

Molecular patterns of the NO-sGC-cGMP pathway in progressive and regressive liver fibrosis models

Abstract The nitric oxide (NO)—soluble guanylate cyclase (sGC)—cyclic guanosine-monophosphate (cGMP) pathway is impaired in liver fibrosis. We investigated expression patterns of NO-sGC-cGMP components via RT-qPCR in various rat models of liver fibrosis and murine models of liver fibrosis regression...

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Main Authors: Thomas Sorz-Nechay, Ksenia Brusilovskaya, Philipp Königshofer, Benedikt S. Hofer, Oleksandr Petrenko, Benedikt Simbrunner, Vlad Taru, Katharina Bonitz, Henriette Horstmeier, Kerstin Zinober, Katharina Regnat, Carolin Lackner, Michael Trauner, Peng Sun, Ines Truebenbach, Stefan G. Kauschke, Philipp Schwabl, Thomas Reiberger
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Soluble guanylate cyclase
Liver fibrosis
Portal hypertension
Liver fibrosis regression
Liver cirrhosis
Online Access:https://doi.org/10.1038/s41598-025-12381-0
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