An experimental chimeric hepatitis E virus vaccine elicits both local and systemic immune responses

An experimental chimeric hepatitis E virus vaccine elicits both local and systemic immune responses

IntroductionThe development of a hepatitis E virus (HEV) vaccine is critical, with ORF2 capsid protein as the main target. We previously demonstrated that oral coadministration of recombinant ORF2 with immunomodulatory bacterium-like-particles (IBLP) induces a specific immune response in mice, parti...

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Bibliographic Details
Main Authors: Melisa Florencia Müller, Jacinto Sacur, Julia Matias Brancher, María Daniela Vera, Lorena Arce, María Fernanda Raya-Tonetti, Haruki Kitazawa, Julio Villena, María Guadalupe Vizoso-Pinto
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Microbiology
Subjects:
hepatitis
antigen-display
lactic acid bacteria
recombinant antigen
ORF2
immunomodulatory bacterium-like-particles
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2024.1512018/full
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