Enhancing radiosensitivity of osteosarcoma by ITGB3 knockdown: a mechanism linked to enhanced osteogenic differentiation status through JNK/c-JUN/RUNX2 pathway activation

Enhancing radiosensitivity of osteosarcoma by ITGB3 knockdown: a mechanism linked to enhanced osteogenic differentiation status through JNK/c-JUN/RUNX2 pathway activation

Abstract Background The prognosis of osteosarcoma has improved little over the past few decades, with radioresistance being a contributing factor. Effective radiosensitizing targets and novel mechanisms for treating osteosarcoma are urgently needed. Research on the impact of regulating differentiati...

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Bibliographic Details
Main Authors:	Qiujian Lian, Hu Liu, Jingyan Li, Cheng Luo, Chang Liu, Haonan Zhao, Peijun Dai, Bingxuan Wang, Huipeng Zhou, Xin Jiang, Zhiwei Wang, Suchi Qiao
Format:	Article
Language:	English
Published:	BMC 2025-05-01
Series:	Journal of Experimental & Clinical Cancer Research
Subjects:	ITGB3 Radiosensitizing Osteosarcoma JNK RUNX2 Osteogenic differentiation
Online Access:	https://doi.org/10.1186/s13046-025-03417-4
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