Enhancing radiosensitivity of osteosarcoma by ITGB3 knockdown: a mechanism linked to enhanced osteogenic differentiation status through JNK/c-JUN/RUNX2 pathway activation

Enhancing radiosensitivity of osteosarcoma by ITGB3 knockdown: a mechanism linked to enhanced osteogenic differentiation status through JNK/c-JUN/RUNX2 pathway activation

Abstract Background The prognosis of osteosarcoma has improved little over the past few decades, with radioresistance being a contributing factor. Effective radiosensitizing targets and novel mechanisms for treating osteosarcoma are urgently needed. Research on the impact of regulating differentiati...

Full description

Saved in:
Bibliographic Details
Main Authors: Qiujian Lian, Hu Liu, Jingyan Li, Cheng Luo, Chang Liu, Haonan Zhao, Peijun Dai, Bingxuan Wang, Huipeng Zhou, Xin Jiang, Zhiwei Wang, Suchi Qiao
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
ITGB3
Radiosensitizing
Osteosarcoma
JNK
RUNX2
Osteogenic differentiation
Online Access:https://doi.org/10.1186/s13046-025-03417-4
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1186/s13046-025-03417-4

Similar Items