Exploring the influence of cheese consumption on blood metabolites: Implications for disease pathogenesis, with a focus on essential hypertension
ABSTRACT: This study examines the causal effects of cheese consumption on blood metabolites and essential hypertension using Mendelian randomization (MR). Genome-wide association study data from the Open GWAS project and FinnGen Biobank were analyzed, focusing on cheese intake, 249 metabolic traits,...
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| Language: | English |
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Elsevier
2025-01-01
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| Series: | Journal of Dairy Science |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0022030224012529 |
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| author | Yanjiang Yang Xiaorui Wang Wenwen Yang |
| author_facet | Yanjiang Yang Xiaorui Wang Wenwen Yang |
| author_sort | Yanjiang Yang |
| collection | DOAJ |
| description | ABSTRACT: This study examines the causal effects of cheese consumption on blood metabolites and essential hypertension using Mendelian randomization (MR). Genome-wide association study data from the Open GWAS project and FinnGen Biobank were analyzed, focusing on cheese intake, 249 metabolic traits, and hypertension. Instrumental variables were selected based on strict criteria, and causal relationships were assessed using inverse-variance weighing, weighted-median, and MR-Egger methods. Cheese consumption significantly influenced 118 metabolic traits, including AA, cholesterol esters, and triglycerides. Notably, it was linked to a reduction in hypertension risk (odds ratio = 0.652; 95% CI: 0.541–0.785). Mediation analysis identified 50 metabolic traits as intermediaries, accounting for 0.88% to 8.25% of the total effect. These findings suggest that moderate cheese intake may benefit cardiovascular health by lowering hypertension risk, emphasizing the importance of cheese type and dietary context in health recommendations. |
| format | Article |
| id | doaj-art-bedcf2a8b6fd4dd2ac9bed3b59ac81e7 |
| institution | Kabale University |
| issn | 0022-0302 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Dairy Science |
| spelling | doaj-art-bedcf2a8b6fd4dd2ac9bed3b59ac81e72024-12-26T08:52:18ZengElsevierJournal of Dairy Science0022-03022025-01-011081119135Exploring the influence of cheese consumption on blood metabolites: Implications for disease pathogenesis, with a focus on essential hypertensionYanjiang Yang0Xiaorui Wang1Wenwen Yang2Department of Rheumatology and Immunology, The People's Hospital of Qiandongnan Autonomous Prefecture, Kaili 556000, Guizhou Province, ChinaSchool of Pharmacy, Chengdu University, Chengdu 610106, ChinaThe First Clinical Medical College, Lanzhou University, Lanzhou 730000, Gansu Province, China; Corresponding authorABSTRACT: This study examines the causal effects of cheese consumption on blood metabolites and essential hypertension using Mendelian randomization (MR). Genome-wide association study data from the Open GWAS project and FinnGen Biobank were analyzed, focusing on cheese intake, 249 metabolic traits, and hypertension. Instrumental variables were selected based on strict criteria, and causal relationships were assessed using inverse-variance weighing, weighted-median, and MR-Egger methods. Cheese consumption significantly influenced 118 metabolic traits, including AA, cholesterol esters, and triglycerides. Notably, it was linked to a reduction in hypertension risk (odds ratio = 0.652; 95% CI: 0.541–0.785). Mediation analysis identified 50 metabolic traits as intermediaries, accounting for 0.88% to 8.25% of the total effect. These findings suggest that moderate cheese intake may benefit cardiovascular health by lowering hypertension risk, emphasizing the importance of cheese type and dietary context in health recommendations.http://www.sciencedirect.com/science/article/pii/S0022030224012529cheese consumptionMendelian randomizationblood metabolitesessential hypertension |
| spellingShingle | Yanjiang Yang Xiaorui Wang Wenwen Yang Exploring the influence of cheese consumption on blood metabolites: Implications for disease pathogenesis, with a focus on essential hypertension Journal of Dairy Science cheese consumption Mendelian randomization blood metabolites essential hypertension |
| title | Exploring the influence of cheese consumption on blood metabolites: Implications for disease pathogenesis, with a focus on essential hypertension |
| title_full | Exploring the influence of cheese consumption on blood metabolites: Implications for disease pathogenesis, with a focus on essential hypertension |
| title_fullStr | Exploring the influence of cheese consumption on blood metabolites: Implications for disease pathogenesis, with a focus on essential hypertension |
| title_full_unstemmed | Exploring the influence of cheese consumption on blood metabolites: Implications for disease pathogenesis, with a focus on essential hypertension |
| title_short | Exploring the influence of cheese consumption on blood metabolites: Implications for disease pathogenesis, with a focus on essential hypertension |
| title_sort | exploring the influence of cheese consumption on blood metabolites implications for disease pathogenesis with a focus on essential hypertension |
| topic | cheese consumption Mendelian randomization blood metabolites essential hypertension |
| url | http://www.sciencedirect.com/science/article/pii/S0022030224012529 |
| work_keys_str_mv | AT yanjiangyang exploringtheinfluenceofcheeseconsumptiononbloodmetabolitesimplicationsfordiseasepathogenesiswithafocusonessentialhypertension AT xiaoruiwang exploringtheinfluenceofcheeseconsumptiononbloodmetabolitesimplicationsfordiseasepathogenesiswithafocusonessentialhypertension AT wenwenyang exploringtheinfluenceofcheeseconsumptiononbloodmetabolitesimplicationsfordiseasepathogenesiswithafocusonessentialhypertension |