PF4 regulates neuronal ferroptosis in cerebral hemorrhage through CXCR3/PI3K/AKT/Nrf2 pathway

PF4 regulates neuronal ferroptosis in cerebral hemorrhage through CXCR3/PI3K/AKT/Nrf2 pathway

Inhibiting ferroptosis represents a promising strategy for managing neuronal injury caused by intracerebral hemorrhage (ICH). Platelet factor 4 (PF4), a chemokine with diverse biological functions, has an unclear role in ICH and its impact on neuronal ferroptosis. To investigate this, a hemin-induce...

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Bibliographic Details
Main Authors: Na Hu, Yunfeng Li, Guohong Zhang, Wei Wang, Liping An, Ran An, Yu Liu
Format: Article
Language:English
Published: Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina 2024-11-01
Series:Biomolecules & Biomedicine
Subjects:
Platelet factor 4
PF4
intracerebral hemorrhage
ICH
ferroptosis
C-X-C motif chemokine receptor 3
Online Access:https://www.bjbms.org/ojs/index.php/bjbms/article/view/11415
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