Replication Restriction of Influenza A(H5N1) Clade 2.3.4.4b Viruses by Human Immune Factor, 2023–2024

Replication Restriction of Influenza A(H5N1) Clade 2.3.4.4b Viruses by Human Immune Factor, 2023–2024

We show that human myxovirus resistance protein 1 (MxA) suppresses replication of highly pathogenic avian influenza A(H5N1) viruses isolated from mammals in vitro and in MxA-transgenic mice. However, H5N1 can evade MxA restriction through replacement of individual viral polymerase complex component...

Full description

Saved in:
Bibliographic Details
Main Authors: Jakob Ankerhold, Susanne Kessler, Martin Beer, Martin Schwemmle, Kevin Ciminski
Format: Article
Language:English
Published: Centers for Disease Control and Prevention 2025-01-01
Series:Emerging Infectious Diseases
Subjects:
influenza
highly pathogenic avian influenza A(H5N1) viruses
H5N1 clade 2.3.4.4b
virus
MxA
zoonotic transmission
Online Access:https://wwwnc.cdc.gov/eid/article/31/1/24-1236_article
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items