Formulation Design, Optimization, and Evaluation of Solid Lipid Nanoparticles Loaded With an Antiviral Drug Tenofovir Using Box–Behnken Design for Boosting Oral Bioavailability
Conclusion: This study suggests the potential of SLNs in overcoming bioavailability issues, particularly low permeability, gut metabolism, and P-gp efflux transport.
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-01-01
|
| Series: | Advances in Pharmacological and Pharmaceutical Sciences |
| Online Access: | http://dx.doi.org/10.1155/2024/5248746 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841555858093244416 |
|---|---|
| author | Sri Rekha M. Sangeetha S. |
| author_facet | Sri Rekha M. Sangeetha S. |
| author_sort | Sri Rekha M. |
| collection | DOAJ |
| description | Conclusion: This study suggests the potential of SLNs in overcoming bioavailability issues, particularly low permeability, gut metabolism, and P-gp efflux transport. |
| format | Article |
| id | doaj-art-bebc5d7ad9d54237ba7963921458bdb9 |
| institution | Kabale University |
| issn | 2633-4690 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Pharmacological and Pharmaceutical Sciences |
| spelling | doaj-art-bebc5d7ad9d54237ba7963921458bdb92025-01-08T00:00:03ZengWileyAdvances in Pharmacological and Pharmaceutical Sciences2633-46902024-01-01202410.1155/2024/5248746Formulation Design, Optimization, and Evaluation of Solid Lipid Nanoparticles Loaded With an Antiviral Drug Tenofovir Using Box–Behnken Design for Boosting Oral BioavailabilitySri Rekha M.0Sangeetha S.1Department of PharmaceuticsDepartment of PharmaceuticsConclusion: This study suggests the potential of SLNs in overcoming bioavailability issues, particularly low permeability, gut metabolism, and P-gp efflux transport.http://dx.doi.org/10.1155/2024/5248746 |
| spellingShingle | Sri Rekha M. Sangeetha S. Formulation Design, Optimization, and Evaluation of Solid Lipid Nanoparticles Loaded With an Antiviral Drug Tenofovir Using Box–Behnken Design for Boosting Oral Bioavailability Advances in Pharmacological and Pharmaceutical Sciences |
| title | Formulation Design, Optimization, and Evaluation of Solid Lipid Nanoparticles Loaded With an Antiviral Drug Tenofovir Using Box–Behnken Design for Boosting Oral Bioavailability |
| title_full | Formulation Design, Optimization, and Evaluation of Solid Lipid Nanoparticles Loaded With an Antiviral Drug Tenofovir Using Box–Behnken Design for Boosting Oral Bioavailability |
| title_fullStr | Formulation Design, Optimization, and Evaluation of Solid Lipid Nanoparticles Loaded With an Antiviral Drug Tenofovir Using Box–Behnken Design for Boosting Oral Bioavailability |
| title_full_unstemmed | Formulation Design, Optimization, and Evaluation of Solid Lipid Nanoparticles Loaded With an Antiviral Drug Tenofovir Using Box–Behnken Design for Boosting Oral Bioavailability |
| title_short | Formulation Design, Optimization, and Evaluation of Solid Lipid Nanoparticles Loaded With an Antiviral Drug Tenofovir Using Box–Behnken Design for Boosting Oral Bioavailability |
| title_sort | formulation design optimization and evaluation of solid lipid nanoparticles loaded with an antiviral drug tenofovir using box behnken design for boosting oral bioavailability |
| url | http://dx.doi.org/10.1155/2024/5248746 |
| work_keys_str_mv | AT srirekham formulationdesignoptimizationandevaluationofsolidlipidnanoparticlesloadedwithanantiviraldrugtenofovirusingboxbehnkendesignforboostingoralbioavailability AT sangeethas formulationdesignoptimizationandevaluationofsolidlipidnanoparticlesloadedwithanantiviraldrugtenofovirusingboxbehnkendesignforboostingoralbioavailability |