γδ T Cell‐mediated Tumor Immunity is Tightly Regulated by STING and TGF‐β Signaling Pathways

γδ T Cell‐mediated Tumor Immunity is Tightly Regulated by STING and TGF‐β Signaling Pathways

Abstract The STING pathway plays a critical role in tumor immunosurveillance. However, the precise mechanisms by which STING regulates gamma delta (γδ) T cell function during tumor progression remain unclear. Herein, we find that tumor‐derived cyclic GMP‐AMP (cGAMP) activates a distinct STING pathwa...

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Main Authors: Jing Luo, Shengli Wang, Quanli Yang, Qianqian Fu, Chuyun Zhu, Tao Li, Shuxian Yang, Yin Zhao, Rong Guo, Xiaosong Ben, Yuzhen Zheng, Sitao Li, Guang Yang, Hongru Zhang, Hui Xiao, Zhengfan Jiang, Nan Yan, Dieter Kabelitz, Guodong Sun, Zvi Granot, Ligong Lu, Fuping You, Jianlei Hao, Zhinan Yin
Format: Article
Language:English
Published: Wiley 2025-01-01
Series:Advanced Science
Subjects:
Eomes
IFN‐γ
STING
tumor immunity
γδ T cells
Online Access:https://doi.org/10.1002/advs.202404432
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