Mining the human gut microbiome for novel stress resistance genes
With the rapid advances in sequencing technologies in recent years, the human genome is now considered incomplete without the complementing microbiome, which outnumbers human genes by a factor of one hundred. The human microbiome, and more specifically the gut microbiome, has received considerable a...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2012-07-01
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| Series: | Gut Microbes |
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| Online Access: | https://www.tandfonline.com/doi/10.4161/gmic.20984 |
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| author | Eamonn P. Culligan Julian R. Marchesi Colin Hill Roy D. Sleator |
| author_facet | Eamonn P. Culligan Julian R. Marchesi Colin Hill Roy D. Sleator |
| author_sort | Eamonn P. Culligan |
| collection | DOAJ |
| description | With the rapid advances in sequencing technologies in recent years, the human genome is now considered incomplete without the complementing microbiome, which outnumbers human genes by a factor of one hundred. The human microbiome, and more specifically the gut microbiome, has received considerable attention and research efforts over the past decade. Many studies have identified and quantified “who is there?,” while others have determined some of their functional capacity, or “what are they doing?” In a recent study, we identified novel salt-tolerance loci from the human gut microbiome using combined functional metagenomic and bioinformatics based approaches. Herein, we discuss the identified loci, their role in salt-tolerance and their importance in the context of the gut environment. We also consider the utility and power of functional metagenomics for mining such environments for novel genes and proteins, as well as the implications and possible applications for future research. |
| format | Article |
| id | doaj-art-beaaa0198c9a4e3b824efb416dd99b8f |
| institution | Kabale University |
| issn | 1949-0976 1949-0984 |
| language | English |
| publishDate | 2012-07-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Gut Microbes |
| spelling | doaj-art-beaaa0198c9a4e3b824efb416dd99b8f2024-11-12T15:48:08ZengTaylor & Francis GroupGut Microbes1949-09761949-09842012-07-013439439710.4161/gmic.20984Mining the human gut microbiome for novel stress resistance genesEamonn P. Culligan0Julian R. Marchesi1Colin Hill2Roy D. Sleator3Alimentary Pharmabiotic Centre; University College Cork; Cork, IrelandAlimentary Pharmabiotic Centre; University College Cork; Cork, IrelandAlimentary Pharmabiotic Centre; University College Cork; Cork, IrelandDepartment of Biological Sciences; Cork Institute of Technology; Bishopstown, Cork, IrelandWith the rapid advances in sequencing technologies in recent years, the human genome is now considered incomplete without the complementing microbiome, which outnumbers human genes by a factor of one hundred. The human microbiome, and more specifically the gut microbiome, has received considerable attention and research efforts over the past decade. Many studies have identified and quantified “who is there?,” while others have determined some of their functional capacity, or “what are they doing?” In a recent study, we identified novel salt-tolerance loci from the human gut microbiome using combined functional metagenomic and bioinformatics based approaches. Herein, we discuss the identified loci, their role in salt-tolerance and their importance in the context of the gut environment. We also consider the utility and power of functional metagenomics for mining such environments for novel genes and proteins, as well as the implications and possible applications for future research.https://www.tandfonline.com/doi/10.4161/gmic.20984functional metagenomicshuman gut microbiomesalt tolerancemeta-biotechnology |
| spellingShingle | Eamonn P. Culligan Julian R. Marchesi Colin Hill Roy D. Sleator Mining the human gut microbiome for novel stress resistance genes Gut Microbes functional metagenomics human gut microbiome salt tolerance meta-biotechnology |
| title | Mining the human gut microbiome for novel stress resistance genes |
| title_full | Mining the human gut microbiome for novel stress resistance genes |
| title_fullStr | Mining the human gut microbiome for novel stress resistance genes |
| title_full_unstemmed | Mining the human gut microbiome for novel stress resistance genes |
| title_short | Mining the human gut microbiome for novel stress resistance genes |
| title_sort | mining the human gut microbiome for novel stress resistance genes |
| topic | functional metagenomics human gut microbiome salt tolerance meta-biotechnology |
| url | https://www.tandfonline.com/doi/10.4161/gmic.20984 |
| work_keys_str_mv | AT eamonnpculligan miningthehumangutmicrobiomefornovelstressresistancegenes AT julianrmarchesi miningthehumangutmicrobiomefornovelstressresistancegenes AT colinhill miningthehumangutmicrobiomefornovelstressresistancegenes AT roydsleator miningthehumangutmicrobiomefornovelstressresistancegenes |